| Revision as of 14:31, 5 December 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 456800582 of page Propantheline_bromide for the Chem/Drugbox validation project (updated: 'DrugBank'). |
Latest revision as of 06:01, 13 November 2024 edit Slothwizard (talk | contribs)Extended confirmed users1,361 editsmNo edit summaryTags: Visual edit Mobile edit Mobile web edit |
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{{Short description|Drug for functional gastrointestinal disorders}} |
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}} |
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{{Refimprove|date=March 2009}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| Verifiedfields = changed |
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| verifiedrevid = 456483224 |
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| verifiedrevid = 464216255 |
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| IUPAC_name = ''N''-isopropyl-''N''-methyl-''N''-{2-ethyl}propan-2-aminium bromide |
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| IUPAC_name = ''N''-isopropyl-''N''-methyl-''N''-<nowiki/>{2-ethyl}propan-2-aminium bromide |
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| image = Proprantheline bromide.svg |
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| image = Proprantheline bromide.svg |
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<!--Clinical data-->| tradename = Pro-Banthine, others |
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<!--Clinical data--> |
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| tradename = |
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| Drugs.com = {{drugs.com|monograph|propantheline_bromide}} |
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| Drugs.com = {{drugs.com|monograph|propantheline_bromide}} |
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| MedlinePlus = a684020 |
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| MedlinePlus = a684020 |
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| legal_UK = <!-- GSL / P / POM / CD --> |
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| legal_UK = <!-- GSL / P / POM / CD --> |
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| legal_US = <!-- OTC / Rx-only --> |
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| legal_US = <!-- OTC / Rx-only --> |
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| routes_of_administration = ] |
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| class = ] |
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<!--Identifiers--> |
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<!--Identifiers-->| CAS_number_Ref = {{cascite|correct|CAS}} |
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| CAS_number = 50-34-0 |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 298-50-0 |
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| CAS_supplemental = {{CAS|50-34-0}} |
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| ATC_prefix = A03 |
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| ATC_prefix = A03 |
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| ATC_suffix = AB05 |
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| ATC_suffix = AB05 |
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| PubChem = 9279 |
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| PubChem = 9279 |
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| IUPHAR_ligand = 329 |
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| DrugBank_Ref = {{drugbankcite|changed|drugbank}} |
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| DrugBank_Ref = {{drugbankcite|changed|drugbank}} |
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| DrugBank = <!-- blanked - oldvalue: APRD00177 --> |
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| DrugBank = DB00782 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 8922 |
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| ChemSpiderID = 8922 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 1306V2B0Q8 |
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| UNII = UX9Z118X9F |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL = 1240 |
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| ChEMBL = 1240 |
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| KEGG_Ref = {{keggcite|changed|kegg}} |
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| KEGG = D00481 |
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<!--Chemical data--> |
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<!--Chemical data-->| C = 23 |
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| C=23 | H=30 | N=1 | O=3 |
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| H = 30 |
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| molecular_weight = 368.489 g/mol |
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| N = 1 |
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| O = 3 |
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| smiles = .O=C(OCC(C(C)C)(C(C)C)C)C2c3c(Oc1c2cccc1)cccc3 |
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| smiles = .O=C(OCC(C(C)C)(C(C)C)C)C2c3c(Oc1c2cccc1)cccc3 |
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| InChI = 1/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H/q+1;/p-1 |
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| InChIKey = XLBIBBZXLMYSFF-REWHXWOFAD |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H/q+1;/p-1 |
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| StdInChI = 1S/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H/q+1;/p-1 |
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| StdInChIKey = XLBIBBZXLMYSFF-UHFFFAOYSA-M |
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| StdInChIKey = XLBIBBZXLMYSFF-UHFFFAOYSA-M |
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}} |
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}} |
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'''Propantheline bromide''' (]) is an ] medication used for the treatment of excessive sweating (]), cramps or spasms of the stomach, intestines (gut), or bladder, and involuntary urination (]). It can also be used to control the symptoms of ] (IBS) and similar conditions. This medication can also be used for patients who experience intense ] symptoms while tapering off of ]. |
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<ref>{{cite book|title=Female Urology, Urogynecology, and Voiding Dysfunction| vauthors = Vasavada SP, Appell R, Sand PK, Raz S |publisher=Informa Health Care|year= 2004|ISBN=0-8247-5426-3}}</ref> |
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==Indications== |
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By relaxing the gut muscle, propantheline can relieve pain in conditions caused by ] of the muscle in the gut. Relaxing the smooth muscle in the ] prevents the involuntary spasms that can allow leakage of ] from the bladder in the condition known as ] (involuntary urination in adults). Propantheline can also be used to treat excessive ] because acetylcholine block also reduces secretions such as sweat and ]. |
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==Adverse effects== |
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Side effects of propantheline include ], ], ], ], and ]. |
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This can also be prescribed by dentists for certain patients who salivate excessively. By giving this medication, it becomes easier to do "dry" dentistry. |
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==Mechanism of action== |
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Propantheline is one of a group of ] medications which work by blocking the action of the chemical messenger ], which is produced by nerve cells, to ]s present in various ] tissues, in places such as the gut, bladder and eye. Normally, the binding of acetylcholine induces involuntary smooth muscular contractions. |
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==References== |
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{{reflist}} |
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{{Drugs for functional gastrointestinal disorders}} |
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{{Muscarinic acetylcholine receptor modulators}} |
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] |
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] |
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] |
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] |
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] |
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] |
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] |
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] |