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Revision as of 10:36, 16 December 2010 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers from ChemSpider, CommonChemistry and FDA for the Chem/Drugbox validation project - Updated: InChI1->InChI StdInChI StdInChIKey.← Previous edit		Latest revision as of 14:40, 24 January 2024 edit undoMaxim Masiutin (talk | contribs)Extended confirmed users, IP block exemptions, Pending changes reviewers31,043 edits Used lowercase "cite" template everywhere for consistency. Added the cs1 style template to denote Vancouver ("vanc") citation style, because references contain "vauthors" attribute to specify the list of authors.
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			{{short description|Chemical compound}}
			{{cs1 config|name-list-style=vanc}}
	{{chembox		{{chembox
			| Verifiedfields = changed
⚫	| verifiedrevid = 395226561
			| Watchedfields = changed
		⚫	| verifiedrevid = 464403469
	| Name = Sodium pyruvate		| Name = Sodium pyruvate
	| ImageFile = Sodium pyruvate.png		| ImageFile = Sodium pyruvate.png
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	| ImageSizeR1 = 80px		| ImageSizeR1 = 80px
	| ImageNameR1 = The sodium cation		| ImageNameR1 = The sodium cation
			| PIN = Sodium 2-oxopropanoate
	| OtherNames = α-ketopropionic acid sodium salt
			| OtherNames = {{bulletedlist|α-Ketopropionic acid sodium salt|2-Oxopropanoic acid sodium salt|Pyruvic acid sodium salt}}
	2-oxopropanoic acid sodium salt
	Pyruvic acid sodium salt
	| Section1 = {{Chembox Identifiers		| Section1 = {{Chembox Identifiers
			| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
	| ChemSpiderID = 7931
	| PubChem = 8224		| ChemSpiderID = 7931
			| ChEMBL_Ref = {{ebicite|correct|EBI}}
			| ChEMBL = 181886
			| PubChem = 23662274
	| UNII_Ref = {{fdacite|correct|FDA}}		| UNII_Ref = {{fdacite|correct|FDA}}
	| UNII = POD38AIF08		| UNII = POD38AIF08
	| InChI = 1/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1		| InChI = 1/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1
	| InChIKey = DAEPDZWVDSPTHF-REWHXWOFAL		| InChIKey = DAEPDZWVDSPTHF-REWHXWOFAL
			| ChEBI_Ref = {{ebicite|correct|EBI}}
			| ChEBI = 50144
	| SMILES = .C(=O)C(=O)C		| SMILES = .C(=O)C(=O)C
			| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
	| StdInChI = 1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1		| StdInChI = 1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1
			| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
	| StdInChIKey = DAEPDZWVDSPTHF-UHFFFAOYSA-M		| StdInChIKey = DAEPDZWVDSPTHF-UHFFFAOYSA-M
	| CASNo_Ref = {{cascite|correct|CAS}}		| CASNo_Ref = {{cascite|correct|CAS}}
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	}}		}}
	| Section2 = {{Chembox Properties		| Section2 = {{Chembox Properties
			| C=3 | H=3 | Na=1 | O=3
	| Formula = C<sub>3</sub>H<sub>3</sub>NaO<sub>3</sub>
	| MolarMass = 110.0 g/mol
	| Density =		| Density =
	| Solvent = other solvents
	| SolubleOther = 100 mg/mL
	| MeltingPt =		| MeltingPt =
	| BoilingPt =}}		| BoilingPt =}}
	}}		}}
⚫	'''Sodium pyruvate''' is commonly added to cell culture media as an additional source of energy, but may also have protective effects against ]. This was reported by Giandomenico ''et al.''.<ref>{{cite journal | author = Giandomenico AR, Cerniglia GE, Biaglow JE, Stevens CW, Koch CJ| title = The importance of sodium pyruvate in assessing damage produced by hydrogen peroxide. | journal = Free Radic Biol Med| volume = 23 | issue = 3 | pages = 426–34 | year = 1997 | pmid = 9214579 | doi = 10.1016/S0891-5849(97)00113-5 | url = }}</ref> and has been confirmed by several independent groups.
		⚫	'''Sodium pyruvate''' is a ] of the conjugate anion form of ], known as pyruvate. It is commonly added to cell culture media as an additional source of energy, but may also have protective effects against ]. This was reported by Giandomenico ''et al''.<ref>{{cite journal |vauthors=Giandomenico AR, Cerniglia GE, Biaglow JE, Stevens CW, Koch CJ | title = The importance of sodium pyruvate in assessing damage produced by hydrogen peroxide. | journal = Free Radic Biol Med| volume = 23 | issue = 3 | pages = 426–34 | year = 1997 | pmid = 9214579 | doi = 10.1016/S0891-5849(97)00113-5 | doi-access = free }}</ref> and has been confirmed by several independent groups.
⚫	==References==
⚫	{{reflist}}
			Due to pyruvate being an intermediate in many pathways for metabolism including ], sodium pyruvate has been used in many experiments involving cell cultures to provide more energy. In adipocytes it was found that sodium pyruvate promoted increased uptake of insulin-mediated glucose.<ref name=":0">{{cite journal|last1=Pandit|first1=Bijan|last2=Sarkar|first2=Abhijit|last3=Sinha|first3=Biswajit|date=2016|title=Solution thermodynamics of sodium pyruvate in aqueous glycine solutions at T 298.15-313.15 K|journal=Journal of the Serbian Chemical Society|volume=81|issue=11|pages=1283–1294|doi=10.2298/jsc151031034p|issn=0352-5139|doi-access=free}}</ref> In the body, one way in which sodium pyruvate provides energy to cells is through pyruvate conversion to acetyl-CoA which then can enter the TCA cycle which produces energy and is linked to other energy producing processes.<ref name=":0" />
⚫	]
			Along with having antioxidant properties and energy producing effects, sodium pyruvate has the ability to cross the blood-brain barrier and is used in several studies on brain injury because of these characteristics.<ref>{{cite journal|last1=Hwang|first1=Ji-Sun|last2=Kim|first2=Song-Yi|last3=Jung|first3=Eun-Hye|last4=Kwon|first4=Mi-Youn|last5=Kim|first5=Kyoung-Hong|last6=Cho|first6=Hyeongjin|last7=Han|first7=Inn-Oc|date=2015-11-19|title=Exogenous Sodium Pyruvate Stimulates Adipogenesis of 3T3-L1 Cells|journal=Journal of Cellular Biochemistry|volume=117|issue=1|pages=39–48|doi=10.1002/jcb.25244|pmid=26053972|s2cid=5100370 |issn=0730-2312}}</ref><ref>{{cite journal|last1=Fukushima|first1=Masamichi|last2=Lee|first2=Stefan M.|last3=Moro|first3=Nobuhiro|last4=Hovda|first4=David A.|last5=Sutton|first5=Richard L.|date=July 2009|title=Metabolic and Histologic Effects of Sodium Pyruvate Treatment in the Rat after Cortical Contusion Injury|journal=Journal of Neurotrauma|volume=26|issue=7|pages=1095–1110|doi=10.1089/neu.2008.0771|pmid=19594384|issn=0897-7151|pmc=2848946}}</ref>
		⚫	==References==
	{{biochem-stub}}
		⚫	{{reflist}}
		⚫	]
	]