| Revision as of 13:22, 10 January 2012 editBeetstra (talk | contribs)Edit filter managers, Administrators172,111 edits Saving copy of the {{chembox}} taken from revid 456897266 of page Thioxanthene for the Chem/Drugbox validation project (updated: 'CASNo'). |
Latest revision as of 16:57, 29 June 2024 edit Sufangxi (talk | contribs)11 editsm Undid revision 1231679557 by Sufangxi (talk)Tag: Undo |
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{{ambox | text = This page contains a copy of the infobox ({{tl|chembox}}) taken from revid of page ] with values updated to verified values.}} |
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{{Chembox |
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{{Chembox |
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| Verifiedfields = changed |
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| Verifiedfields = changed |
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| verifiedrevid = 418300754 |
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| verifiedrevid = 470609193 |
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| ImageFile = Thioxanthene.png |
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| ImageFile = Thioxanthene.png |
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| ImageSize = 200px |
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| ImageSize = 200px |
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| PIN = 9''H''-Thioxanthene<ref>{{cite book |author=] |date=2014 |title=Nomenclature of Organic Chemistry: IUPAC Recommendations and Preferred Names 2013 |publisher=] |pages=213 |doi=10.1039/9781849733069 |isbn=978-0-85404-182-4}}</ref> |
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| IUPACName = 9''H''-thioxanthene |
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| OtherNames = 10''H''-dibenzo(''b'',''e'')thiin |
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| OtherNames = 10''H''-Dibenzothiin |
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| Section1 = {{Chembox Identifiers |
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|Section1={{Chembox Identifiers |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 60819 |
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| ChemSpiderID = 60819 |
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| InChI = 1/C13H10S/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-8H,9H2 |
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| InChI = 1/C13H10S/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-8H,9H2 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = PQJUJGAVDBINPI-UHFFFAOYSA-N |
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| StdInChIKey = PQJUJGAVDBINPI-UHFFFAOYSA-N |
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| CASNo_Ref = {{cascite|correct|??}} |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| CASNo = <!-- blanked - oldvalue: 261-31-4 --> |
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| CASNo = 261-31-4 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| PubChem = 67495 |
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| UNII = 1J3P67894A |
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| ChEBI_Ref = {{ebicite|changed|EBI}} |
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| PubChem = 67495 |
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| ChEBI_Ref = {{ebicite|correct|EBI}} |
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| ChEBI = 51055 |
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| ChEBI = 51055 |
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| SMILES = S2c1ccccc1Cc3c2cccc3 |
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| SMILES = S2c1ccccc1Cc3c2cccc3 |
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| Section2 = {{Chembox Properties |
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|Section2={{Chembox Properties |
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| C = 13 | H = 10 | S = 1 |
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| C=13 | H=10 | S=1 |
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| Section3 = {{Chembox Hazards |
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'''Thioxanthene''' is a ] in which the ] atom in ] is replaced with a ] atom. It is also related to ]. Several of its ]s are used as ]s in the treatment of ] and other ]s. |
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== Derivatives == |
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The derivatives of thioxanthene used clinically as antipsychotics include: |
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* ] (Cloxan, Taractan, Truxal) |
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* ] (Sordinol) |
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* ] (Depixol, Fluanxol) |
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* ] (Navane) |
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* ] (Cisordinol, Clopixol, Acuphase) |
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The therapeutic efficacy of these drugs is related to their ability to ] the ]s in the brain, though they have actions at other sites such as ], ], and ]s as well which mostly contribute to ]s. |
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The thioxanthenes, as a class, are closely related chemically to the ]. The major structural difference is that the nitrogen at position 10 in the phenothiazines is replaced by a carbon atom with a double bond to the side chain.<ref>'']''</ref> This difference is noted in the illustration of flupenthixol, which shows a double-bonded carbon in the number 10 position (opposite the sulfur molecule in the central chain). |
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== References == |
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{{Reflist|2}} |
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== External links == |
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* {{MeshName|Thioxanthenes}} |
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* |
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{{Antipsychotics}} |
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{{Antiemetics}} |
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{{Sedatives}} |
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{{Adrenergics}} |
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{{Dopaminergics}} |
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{{Histaminergics}} |
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{{Serotonergics}} |
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{{Tricyclics}} |
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] |