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Revision as of 16:42, 10 January 2012 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 454697621 of page Zipeprol for the Chem/Drugbox validation project (updated: 'CAS_number').  Latest revision as of 00:45, 2 July 2024 edit Yoshi24517 (talk | contribs)Extended confirmed users, IP block exemptions, Pending changes reviewers, Rollbackers54,803 editsm Reverted edits by 2600:1702:29F1:4040:9C5A:B667:1D65:8DC2 (talk): source? (HG) (3.4.12)Tags: Huggle Rollback 
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{{Short description|Cough suppressant drug}}
{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}}
{{cs1 config|name-list-style=vanc}}
{{Drugbox {{Drugbox
| Verifiedfields = changed
| verifiedrevid = 447812741 | verifiedrevid = 470637387
| IUPAC_name = 1-methoxy- 3-- 1-phenylpropan- 2-ol | IUPAC_name = 1-methoxy- 3-- 1-phenylpropan- 2-ol
| image = zipeprol.png | image = zipeprol.png
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| tradename = | tradename =
| Drugs.com = {{drugs.com|international|zipeprol}} | Drugs.com = {{drugs.com|international|zipeprol}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_AU = <!-- A, B1, B2, B3, C, D, X -->
| pregnancy_US = <!-- A / B / C / D / X --> | pregnancy_US = <!-- A, B, C, D, X -->
| pregnancy_category = | pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> | legal_AU = <!-- Unscheduled, S2, S3, S4, S5, S6, S7, S8, S9 -->
| legal_BR = F2
⚫ | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_BR_comment = <ref>{{Cite web |author=Anvisa |author-link=Brazilian Health Regulatory Agency |date=2023-07-24 |title=RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial |trans-title=Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control|url=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451 |url-status=live |archive-url=https://web.archive.org/web/20230827163149/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451 |archive-date=2023-08-27 |access-date=2023-08-27 |publisher=] |language=pt-BR |publication-date=2023-07-25}}</ref>
⚫ | legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_DE = Anlage II
| legal_US = Schedule I <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status = Schedule II international | legal_CA = Schedule III
⚫ | legal_UK = Class B<!-- GSL, P, POM, CD, Class A, B, C -->
⚫ | legal_US = Schedule I <!-- OTC, Rx-only, Schedule I, II, III, IV, V -->
| legal_UN = P II
| routes_of_administration = Oral | routes_of_administration = Oral


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| metabolism = | metabolism =
| elimination_half-life = | elimination_half-life =
| excretion = | excretion =


<!--Identifiers--> <!--Identifiers-->
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = <!-- blanked - oldvalue: 34758-83-3 --> | CAS_number = 34758-83-3
| ATC_prefix = R05 | ATC_prefix = R05
| ATC_suffix = DB15 | ATC_suffix = DB15
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<!--Chemical data--> <!--Chemical data-->
| C=23 | H=32 | N=2 | O=3 | C=23 | H=32 | N=2 | O=3
| molecular_weight = 384.512 g/mol
| smiles = OC(CN1CCN(CC1)CC(OC)c2ccccc2)C(OC)c3ccccc3 | smiles = OC(CN1CCN(CC1)CC(OC)c2ccccc2)C(OC)c3ccccc3
| InChI = 1/C23H32N2O3/c1-27-22(19-9-5-3-6-10-19)18-25-15-13-24(14-16-25)17-21(26)23(28-2)20-11-7-4-8-12-20/h3-12,21-23,26H,13-18H2,1-2H3
| InChIKey = VSTNNAYSCJQCQI-UHFFFAOYAC
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C23H32N2O3/c1-27-22(19-9-5-3-6-10-19)18-25-15-13-24(14-16-25)17-21(26)23(28-2)20-11-7-4-8-12-20/h3-12,21-23,26H,13-18H2,1-2H3 | StdInChI = 1S/C23H32N2O3/c1-27-22(19-9-5-3-6-10-19)18-25-15-13-24(14-16-25)17-21(26)23(28-2)20-11-7-4-8-12-20/h3-12,21-23,26H,13-18H2,1-2H3
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| StdInChIKey = VSTNNAYSCJQCQI-UHFFFAOYSA-N | StdInChIKey = VSTNNAYSCJQCQI-UHFFFAOYSA-N
}} }}

'''Zipeprol''' is a centrally acting ] developed in France in the 1970s.<ref>Patent {{cite patent| country=US | number=3718650 | pridate= 1970-03-02 | gdate=1973-02-27 | inventor = Mauvernay RY | title = New Derivatives of Substituted Piperazines}}</ref> It is not a ] derivative (in contrast to ] and ]). Zipeprol acts as a local anaesthetic and has ], ] and ] properties.<ref>{{cite journal | vauthors = Rispat G, Burgi H, Cosnier D, Duchêne-Marullaz P, Streichenberger G | title = General pharmacological properties of a new non-opiate antitussive: zipeprol (3024 CERM). I. Action on respiratory function and acute toxicity | journal = Arzneimittel-Forschung | volume = 26 | issue = 4 | pages = 523–30 | date = April 1976 | pmid = 8057 }}</ref> It is sold with several brand names such as '''Zinolta''' and '''Respilene'''. It is not available in the United States or Canada and has been discontinued in Europe. It is still available in some countries in Asia and South America.

Zipeprol has been misused in Korea, mainly for the hallucinations it produces. Such use has become an issue due to the seizures and various neurological side effects it causes at high dosages.<ref>{{cite journal | vauthors = Chung H, Park M, Hahn E, Choi H, Choi H, Lim M | title = Recent trends of drug abuse and drug-associated deaths in Korea | journal = Annals of the New York Academy of Sciences | volume = 1025 | issue = 1 | pages = 458–64 | date = October 2004 | pmid = 15542749 | doi = 10.1196/annals.1316.056 | bibcode = 2004NYASA1025..458C | s2cid = 10987790 }}</ref>

== References ==
{{reflist}}

{{Cough and cold preparations}}
{{Piperazines}}

]
]
]
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{{respiratory-system-drug-stub}}