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1-deoxypentalenic acid 11beta-hydroxylase (EC 1.14.11.35, PTLH (gene), SAV2991 (gene), PNTH (gene)) is an enzyme with systematic name 1-deoxypentalenic acid,2-oxoglutarate:oxygen oxidoreductase. This enzyme catalyses the following chemical reaction

1-deoxypentalenate + 2-oxoglutarate + O₂ ${\displaystyle \rightleftharpoons }$ 1-deoxy-11beta-hydroxypentalenate + succinate + CO₂

1-Deoxypentalenic acid 11beta-hydroxylase contains Fe(II) and ascorbate.

References

1. You Z, Omura S, Ikeda H, Cane DE (May 2006). "Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlH, a non-heme iron dioxygenase of Streptomyces avermitilis". Journal of the American Chemical Society. 128 (20): 6566–7. doi:10.1021/ja061469i. PMC 2533727. PMID 16704250.
2. You Z, Omura S, Ikeda H, Cane DE, Jogl G (December 2007). "Crystal structure of the non-heme iron dioxygenase PtlH in pentalenolactone biosynthesis". The Journal of Biological Chemistry. 282 (50): 36552–60. doi:10.1074/jbc.M706358200. PMC 3010413. PMID 17942405.

External links

• 1-deoxypentalenic+acid+11beta-hydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 1.14.11