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Following the second game of the regular season in early October, the Lions made a major trade. Future hall of fame quarterback Bobby Layne, the Lions' primary starter for eight seasons and leader of three championship teams, was traded to the Pittsburgh Steelers for third-year quarterback Earl Morrall and two draft choices.
This supposedly led to Layne "cursing" the Lions, allegedly saying that Detroit "would not win for fifty years." The story is considered a hoax, as no contemporaneous account exists and Layne himself denied saying it. (Real or not, the "curse" bedeviled the Lions franchise for the next half-century, and beyond: as of 2024, 66 years after the trade, Detroit has not won another championship, and indeed has won only three playoff contests in that time.) Meanwhile, after losing their first two games without Layne, the Steelers finished at 7–4–1, their best record in over a decade.
The Lions won only one game in the first half of the season (1–4–1), then spilt the final six games; one of the poorest performances by a defending league champion in NFL history. The preseason began on a sour note in mid-August as they lost 35–19 to the 14-point underdog College All-Stars at Soldier Field in Chicago, closing the margin with a late touchdown.
According to the team, a total of 42,154 season tickets were sold by the Lions for the 1957 campaign. The Lions played their home games in Briggs Stadium (Tiger Stadium), which had a regular listed seating capacity of 46,194, with an additional 7,000 bleacher seats for football to bring total capacity to 53,194.