| 2,4-dichlorobenzoyl-CoA reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.63 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2,4-dichlorobenzoyl-CoA reductase (EC 1.3.1.63) is an enzyme that catalyzes the chemical reaction
- 4-chlorobenzoyl-CoA + NADP + HCl 2,4-dichlorobenzoyl-CoA + NADPH + H
2,4-dichlorobenzoyl-CoA + NADPH + HThe 3 substrates of this enzyme are 4-chlorobenzoyl-CoA, NADP, and HCl, whereas its 3 products are 2,4-dichlorobenzoyl-CoA (the thioester of 2,4-dichlorobenzoic acid), NADPH, and H.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating). This enzyme participates in degradation of 2,4-dichlorobenzoate.
References
- Romanov V, Hausinger RP (1996). "NADPH-dependent reductive ortho dehalogenation of 2,4-dichlorobenzoic acid in Corynebacterium sepedonicum KZ-4 and Coryneform bacterium strainNTB-1 via 2,4-dichlorobenzoyl coenzyme A". J. Bacteriol. 178 (9): 2656–61. PMC 177992. PMID 8626335.
| Oxidoreductases: CH–CH oxidoreductases (EC 1.3) | |
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| 1.3.1: NAD/NADP acceptor | |
| 1.3.3: Oxygen acceptor | |
| 1.3.5: Quinone | |
| 1.3.99: Other acceptors | |
| Enzymes | |
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| Activity | |
| Regulation | |
| Classification | |
| Kinetics | |
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