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2-haloacid dehalogenase (configuration-retaining) (EC 3.8.1.11, 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL-2-haloacid dehalogenase, DL-DEXr) is an enzyme with systematic name (S)-2-haloacid dehalogenase (configuration-retaining). This enzyme catalyses the following chemical reaction

(1) (S)-2-haloacid + H₂O ${\displaystyle \rightleftharpoons }$ (S)-2-hydroxyacid + halide

(2) (R)-2-haloacid + H₂O ${\displaystyle \rightleftharpoons }$ (R)-2-hydroxyacid + halide

Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids.

References

1. Weightman AJ, Weightman AL, Slater JH (August 1982). "Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas putida PP3: evidence for two different dehalogenation mechanisms". Journal of General Microbiology. 128 (8): 1755–62. doi:10.1099/00221287-128-8-1755. PMID 7142958.
2. Soda, K.; Kurihara, T.; Liu, J.-Q.; Nardi-Dei, V.; Park, C.; Miyagi, M.; Tsunasawa, S.; Esaki, N. (1996). "Bacterial 2-haloacid dehalogenases: Structures and catalytic properties". Pure Appl. Chem. 68 (11): 2097–2103. doi:10.1351/pac199668112097.

External links

• 2-haloacid+dehalogenase+(configuration-retaining) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 3.8.1