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2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase (EC 3.7.1.13, CarC) is an enzyme with systematic name (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate acylhydrolase. This enzyme catalyses the following chemical reaction

(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H₂O ${\displaystyle \rightleftharpoons }$ anthranilate + (2E)-2-hydroxypenta-2,4-dienoate

This enzyme catalyses the third step in the aerobic degradation pathway of carbazole.

References

1. Nojiri H, Taira H, Iwata K, Morii K, Nam JW, Yoshida T, Habe H, Nakamura S, Shimizu K, Yamane H, Omori T (January 2003). "Purification and characterization of meta-cleavage compound hydrolase from a carbazole degrader Pseudomonas resinovorans strain CA10". Bioscience, Biotechnology, and Biochemistry. 67 (1): 36–45. doi:10.1271/bbb.67.36. PMID 12619671.
2. Riddle RR, Gibbs PR, Willson RC, Benedik MJ (March 2003). "Purification and properties of 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoic acid hydrolase involved in microbial degradation of carbazole". Protein Expression and Purification. 28 (1): 182–9. doi:10.1016/S1046-5928(02)00676-9. PMID 12651123.

External links

• 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate+hydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 3.7.1