2-methylisoborneol synthase

2-methylisoborneol synthase (EC 4.2.3.118, sco7700, 2-MIB cyclase, MIB synthase, MIBS) is an enzyme with systematic name (E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming). This enzyme catalyses the following chemical reaction

(E)-2-methylgeranyl diphosphate + H₂O

\rightleftharpoons

2-methylisoborneol + diphosphate

The product, 2-methylisoborneol, is a characteristic odiferous compound with a musty smell produced by soil microorganisms.

References

Wang CM, Cane DE (July 2008). "Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor". Journal of the American Chemical Society. 130 (28): 8908–9. doi:10.1021/ja803639g. PMC 3023297. PMID 18563898.
Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H (May 2008). "Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol". Proceedings of the National Academy of Sciences of the United States of America. 105 (21): 7422–7. Bibcode:2008PNAS..105.7422K. doi:10.1073/pnas.0802312105. PMC 2387273. PMID 18492804.
Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT (February 2011). "Biosynthesis of 2-methylisoborneol in cyanobacteria". Environmental Science & Technology. 45 (3): 992–8. Bibcode:2011EnST...45..992G. doi:10.1021/es102992p. PMC 3699865. PMID 21174459.

External links

2-methylisoborneol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Carbon–oxygen lyases (EC 4.2) (primarily dehydratases)
4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase
4.2.2: Acting on polysaccharides	Hyaluronate lyase Pectin lyase
4.2.3: Acting on phosphates	Threonine synthase
4.2.99: Other	Carboxymethyloxysuccinate lyase Hydroperoxide lyase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 4.2.3