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Carlos Alcaraz defeated Casper Ruud in the final, 6–4, 2–6, 7–6, 6–3 to win the men's singles tennis title at the 2022 US Open. It was his first major title. He claimed the world No. 1 singles ranking with the win; Ruud, Rafael Nadal, Daniil Medvedev, and Stefanos Tsitsipas were also in contention for the top position. Alcaraz saved a match point en route to the title, in the quarterfinals against Jannik Sinner. Alcaraz became the youngest major champion since Nadal at the 2005 French Open, the youngest US Open champion since Pete Sampras in 1990, the first man born in the 2000s to win a major singles title, and the youngest man to be ranked world No. 1, surpassing Lleyton Hewitt's record. At 23 hours and 39 minutes of play duration across his seven matches, Alcaraz spent the longest time on court in major history (a record later broken by Medvedev at the 2024 Australian Open).
Medvedev was the defending champion, but lost in the fourth round to Nick Kyrgios. Medvedev was the first man outside the Big Four to be the top seed at a major since Andy Roddick at the 2004 Australian Open.
This marked the third consecutive US Open where a player claimed his first major title, after Dominic Thiem in 2020 and Medvedev in 2021. The quarterfinal line-up guaranteed a first-time major champion, while the semifinal line-up marked the first time all four players made their US Open semifinal debut since the inaugural edition in 1881. Frances Tiafoe became the first American man to reach the semifinals since Roddick in 2006, the first African American man to reach the semifinals since Arthur Ashe in 1972, and the first to reach any major semifinal since MaliVai Washington in 1996. Sinner became the youngest man to reach the quarterfinals at all four majors since Novak Djokovic in 2008.
Nadal was vying for a record-extending 23rd major singles title, but lost in the fourth round to Tiafoe. That marked the first US Open since 2000 and the first major since the 2017 Australian Open with neither of the top two seeded men reaching the quarterfinals. This was also the four-time champion's final appearance at the US Open. Three-time champion Djokovic withdrew prior to the tournament as he could not travel to the United States, due to not having complied with the federal government's vaccination policy for non-US citizens against COVID-19.
This was the first edition of US Open to feature a 10-point tie-break, when the score reaches six games all in the deciding set. Pedro Cachin defeated Aljaž Bedene in the first round in the first main-draw 10-point tie-break at the US Open.
The following are the seeded players. Seedings are based on ATP rankings as of August 22, 2022. Rankings and points before are as of August 29, 2022.
Points for the 2021 tournament were not mandatory and are included in the table below only if they counted toward the player's ranking as of August 29, 2022. Players who are not defending points from the 2021 tournament will instead have their 19th best result replaced by their points from the 2022 tournament.
† This column shows either the player's points from the 2021 tournament or his 19th best result (shown in brackets). Only ranking points counting toward the player's ranking as of August 29, 2022, are reflected in the column.
Withdrawn players
The following players would have been seeded, but withdrew before the tournament began.
^ On March 1, 2022, the ATP announced that players from Russia and Belarus will not be allowed to compete under the name or flag of Russia or Belarus following the 2022 Russian invasion of Ukraine. On June 14, 2022, the USTA announced that it will allow all eligible players, regardless of nationality, to compete at the 2022 US Open.