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3-hydroxypropionate dehydrogenase

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Class of enzymes
3-hydroxypropionate dehydrogenase
Identifiers
EC no.1.1.1.59
CAS no.9028-59-5
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In enzymology, a 3-hydroxypropionate dehydrogenase (EC 1.1.1.59) is an enzyme that catalyzes the chemical reaction

3-hydroxypropanoate + NAD {\displaystyle \rightleftharpoons } 3-oxopropanoate + NADH + H

Thus, the two substrates of this enzyme are 3-hydroxypropanoate and NAD, whereas its 3 products are 3-oxopropanoate, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 3-hydroxypropanoate:NAD oxidoreductase. This enzyme participates in beta-alanine metabolism and propanoate metabolism.

References

  • Den H, Robinson WG, Coon MJ (1959). "Enzymatic conversion of beta-hydroxypropionate to malonic semialdehyde". J. Biol. Chem. 234 (7): 1666–1671. PMID 13672942.
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
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