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4-Iodobenzoic acid

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4-Iodobenzoic acid
Names
Preferred IUPAC name 4-Iodobenzoic acid
Other names p-Iodobenzoic acid
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.009.641 Edit this at Wikidata
EC Number
  • 210-603-2
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C7H5IO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)Key: GHICCUXQJBDNRN-UHFFFAOYSA-N
SMILES
  • C1=CC(=CC=C1C(=O)O)I
Properties
Chemical formula C7H5IO2
Molar mass 248.019 g·mol
Appearance white solid
Density 2.18 g/cm
Melting point 270–273 °C (518–523 °F; 543–546 K)
Hazards
GHS labelling:
Pictograms GHS07: Exclamation mark
Signal word Warning
Hazard statements H315, H319, H335
Precautionary statements P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkverify (what is  ?) Infobox references
Chemical compound

4-Iodobenzoic acid, or p-iodobenzoic acid, is an isomer of iodobenzoic acid.

Structure

4-iodobenzoic acid crystallization

X-ray crystallography of 4-iodobenzoic acid has shown that it crystallizes in the solid state as hydrogen-bonded dimers which stack perpendicular to their aromatic rings. The iodine atoms of adjacent dimers are also oriented towards each other due to van der Waals forces.

Preparation

4-Iodobenzoic acid may be prepared in the laboratory by the oxidation of p-iodotoluene with potassium permanganate.

Reactions

The carboxylic acid functionality of 4-iodobenzoic acid undergoes Fischer–Speier esterification with methanol to form the ester methyl 4-iodobenzoate.

References

  1. "4-Iodobenzoic acid". Sigma Aldrich. Retrieved January 31, 2023.
  2. "4-Iodobenzoic acid". pubchem.ncbi.nlm.nih.gov.
  3. "4-Iodobenzoic acid". PubChem. Retrieved 2023-01-21.
  4. ^ Nygren, Cara L.; Wilson, Chick C.; Turner, John F. C. (2005). "On the Solid State Structure of 4-Iodobenzoic Acid". The Journal of Physical Chemistry A. 109 (11): 2586–2593. Bibcode:2005JPCA..109.2586N. doi:10.1021/jp047189b. PMID 16833563.
  5. Varma, P. S.; Panickerp, P. B. (1928). "Influence of substitution on the oxidation of side chains in the benzene nucleus". Proc. 15th Indian Sci. Cong.
  6. Gadzikwa, Tendai; Zeng, Bi-Shun; Hupp, Joseph T.; Nguyen, SonBinh T. (2008). "Ligand-elaboration as a strategy for engendering structural diversity in porous metal–organic framework compounds". Chemical Communications (31): 3672–3674. doi:10.1039/B714160B. PMID 18665295.
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