Misplaced Pages

In enzymology, a 4-methyleneglutamate—ammonia ligase (EC 6.3.1.7) is an enzyme that catalyzes the chemical reaction

ATP + 4-methylene-L-glutamate + NH₃ ${\displaystyle \rightleftharpoons }$ AMP + diphosphate + 4-methylene-L-glutamine

The 3 substrates of this enzyme are ATP, 4-methylene-L-glutamate, and NH₃, whereas its 3 products are AMP, diphosphate, and 4-methylene-L-glutamine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is 4-methylene-L-glutamate:ammonia ligase (AMP-forming). This enzyme is also called 4-methyleneglutamine synthetase. This enzyme participates in c5-branched dibasic acid metabolism.

References

• Winter HC, Su TZ, Dekker EE (1983). "4-methyleneglutamine synthetase: a new amide synthetase present in germinating peanuts" (PDF). Biochem. Biophys. Res. Commun. 111 (2): 484–9. doi:10.1016/0006-291X(83)90332-7. hdl:2027.42/25265. PMID 6838571.

• Biology

• v
• t
• e

• EC 6.3.1
• Enzymes of unknown structure
• Ligase stubs