| 4a-hydroxytetrahydrobiopterin dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.96 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96) catalyzes the chemical reaction
- 4a-hydroxytetrahydrobiopterin 6,7-dihydrobiopterin + H2O
6,7-dihydrobiopterin + H2OThis enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4a-hydroxytetrahydrobiopterin hydro-lyase (6,7-dihydrobiopterin-forming). Other names in common use include 4a-hydroxy-tetrahydropterin dehydratase, pterin-4α-carbinolamine dehydratase, and 4a-hydroxytetrahydrobiopterin hydro-lyase.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1DCO, 1DCP, and 1RU0.
References
- Blau N, Ghisla S, Heizmann CW (1993). "Phenylalanine hydroxylase-stimulating protein/pterin-4 alpha-carbinolamine dehydratase from rat and human liver Purification, characterization, and complete amino acid sequence". J. Biol. Chem. 268 (7): 4828–31. doi:10.1016/S0021-9258(18)53471-2. PMID 8444860.
| Carbon–oxygen lyases (EC 4.2) (primarily dehydratases) | |
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| 4.2.1: Hydro-Lyases | |
| 4.2.2: Acting on polysaccharides | |
| 4.2.3: Acting on phosphates | |
| 4.2.99: Other | |
| Enzymes | |
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| Activity | |
| Regulation | |
| Classification | |
| Kinetics | |
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