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5,6-dimethylbenzimidazole synthase (EC 1.14.99.40, BluB) is an enzyme with systematic name FMNH₂ oxidoreductase (5,6-dimethylbenzimidazole forming). This enzyme catalyses the following chemical reaction

FMNH₂ + NADH + H + O₂ ${\displaystyle \rightleftharpoons }$ 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD + other product

The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH₂ and 2-H from the ribityl 1'-pro-S hydrogen. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in bacteria.

See also

• Cobalamin biosynthesis

References

1. Gray MJ, Escalante-Semerena JC (February 2007). "Single-enzyme conversion of FMNH2 to 5,6-dimethylbenzimidazole, the lower ligand of B12". Proceedings of the National Academy of Sciences of the United States of America. 104 (8): 2921–6. Bibcode:2007PNAS..104.2921G. doi:10.1073/pnas.0609270104. PMC 1815282. PMID 17301238.
2. Ealick SE, Begley TP (March 2007). "Biochemistry: molecular cannibalism". Nature. 446 (7134): 387–8. Bibcode:2007Natur.446..387E. doi:10.1038/446387a. PMID 17377573.
3. Taga ME, Larsen NA, Howard-Jones AR, Walsh CT, Walker GC (March 2007). "BluB cannibalizes flavin to form the lower ligand of vitamin B12". Nature. 446 (7134): 449–53. Bibcode:2007Natur.446..449T. doi:10.1038/nature05611. PMC 2770582. PMID 17377583.

External links

• 5,6-dimethylbenzimidazole+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 1.14.99