59th Regiment or 59th Infantry Regiment may refer to:
- 59th Regiment of Foot (disambiguation), three British Army units carried this name
- 59th (Warwickshire) Searchlight Regiment, Royal Artillery, a unit of the British Army
- 59th Scinde Rifles (Frontier Force), a unit of the British Indian Army
- 59 Medium Regiment (India), a unit of the Indian Army
- 59th Infantry Regiment (United States), a unit of the United States Army
- 59th Air Defense Artillery Regiment, a unit of the United States Army
- American Civil War
- Union (Northern) Army
- 59th Illinois Volunteer Infantry Regiment
- 59th Indiana Infantry Regiment
- 59th New York Volunteer Infantry Regiment
- 59th Ohio Infantry
- Confederate (Southern) Army
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