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6-hydroxy-3-succinoylpyridine 3-monooxygenase (EC 1.14.13.163, 6-hydroxy-3-succinoylpyridine hydroxylase, hspA (gene), hspB (gene)) is an enzyme with systematic name 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing). This enzyme catalyses the following chemical reaction

4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H + O₂ ${\displaystyle \rightleftharpoons }$ 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD + H₂O

6-hydroxy-3-succinoylpyridine 3-monooxygenase catalyses a reaction in the nicotine degradation pathway of Pseudomonas species.

References

1. Tang H, Wang S, Ma L, Meng X, Deng Z, Zhang D, Ma C, Xu P (March 2008). "A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16". Applied and Environmental Microbiology. 74 (5): 1567–74. Bibcode:2008ApEnM..74.1567T. doi:10.1128/AEM.02529-07. PMC 2258644. PMID 18203859.
2. Tang H, Yao Y, Zhang D, Meng X, Wang L, Yu H, Ma L, Xu P (November 2011). "A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida". The Journal of Biological Chemistry. 286 (45): 39179–87. doi:10.1074/jbc.M111.283929. PMC 3234743. PMID 21949128.

External links

• 6-hydroxy-3-succinoylpyridine+3-monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 1.14.13