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In enzymology, a 7,8-dihydroxykynurenate 8,8a-dioxygenase (EC 1.13.11.10) is an enzyme that catalyzes the chemical reaction

7,8-dihydroxykynurenate + O₂ ${\displaystyle \rightleftharpoons }$ 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate

Thus, the two substrates of this enzyme are 7,8-dihydroxykynurenate and O₂, whereas its product is 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing). Other names in common use include 7,8-dihydroxykynurenate oxygenase, and 7,8-dihydroxykynurenate 8,8alpha-dioxygenase. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron.

References

• Seno S, Tokuyama T, Sakan T (1961). "Enzymatic degradation of kynurenic acid". Fed. Proc. 20: 3–7. PMID 13724055.

• Biology

• EC 1.13.11
• Iron enzymes
• Enzymes of unknown structure