AFPC may refer to:
- American Foreign Policy Council, a non-profit organization dedicated to bringing information to those who make or influence the foreign policy of the United States
- Australian Fair Pay Commission, an Australian legislative body created under the Howard Government's "WorkChoices" industrial relations law in 2006
- Air Force Personnel Center, a field operating agency of the U.S. Air Force
- Alliance de la Fonction publique du Canada, or Public Service Alliance of Canada, one of Canada's largest national labour unions
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