Misplaced Pages

ALG13
Identifiers
Aliases	ALG13, CDG1S, CXorf45, GLT28D1, MDS031, TDRD13, YGL047W, EIEE36, UDP-N-acetylglucosaminyltransferase subunit, ALG13 UDP-N-acetylglucosaminyltransferase subunit, DEE36
External IDs	OMIM: 300776; MGI: 1914824; HomoloGene: 78772; GeneCards: ALG13; OMA:ALG13 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq23 Start 111,665,811 bp End 111,760,649 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X F2 Start 143,100,800 bp End 143,157,446 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon right uterine tube endothelial cell mucosa of sigmoid colon canal of the cervix left ovary body of uterus anterior pituitary left uterine tube right ovary Top expressed in zygote morula primary oocyte secondary oocyte tail of embryo embryo yolk sac blastocyst spermatid genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function thiol-dependent deubiquitinase transferase activity peptidase activity cysteine-type peptidase activity hexosyltransferase activity protein binding catalytic activity hydrolase activity glycosyltransferase activity N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity RNA binding Cellular component endoplasmic reticulum membrane endoplasmic reticulum UDP-N-acetylglucosamine transferase complex Biological process metabolism proteolysis dolichol-linked oligosaccharide biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79868 67574 Ensembl ENSG00000101901 ENSMUSG00000041718 UniProt Q9NP73 Q9D8C3 RefSeq (mRNA) NM_001039210 NM_001099922 NM_001168385 NM_001257230 NM_001257231 NM_001257234 NM_001257235 NM_001257237 NM_001257239 NM_001257240 NM_001257241 NM_018466 NM_001324290 NM_001324291 NM_001324292 NM_001324293 NM_001324294 NM_024810 NM_026247 RefSeq (protein) NP_001034299 NP_001093392 NP_001161857 NP_001244159 NP_001244160 NP_001244163 NP_001244164 NP_001244166 NP_001244168 NP_001244169 NP_001244170 NP_001311219 NP_001311220 NP_001311221 NP_001311222 NP_001311223 NP_060936 NP_080523 Location (UCSC) Chr X: 111.67 – 111.76 Mb Chr X: 143.1 – 143.16 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

UDP-N-acetylglucosamine transferase subunit ALG13 homolog, also known as asparagine-linked glycosylation 13 homolog, is an enzyme that in humans is encoded by the ALG13 gene.

Function

The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 (ALG14) homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation.

See also

• Congenital disorder of glycosylation

References

1. ^ GRCh38: Ensembl release 89: ENSG00000101901 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000041718 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: asparagine-linked glycosylation 13 homolog (S. cerevisiae)".
6. Gao XD, Tachikawa H, Sato T, Jigami Y, Dean N (October 2005). "Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation". J. Biol. Chem. 280 (43): 36254–62. doi:10.1074/jbc.M507569200. PMID 16100110.
7. Averbeck N, Keppler-Ross S, Dean N (October 2007). "Membrane topology of the Alg14 endoplasmic reticulum UDP-GlcNAc transferase subunit". J. Biol. Chem. 282 (40): 29081–8. doi:10.1074/jbc.M704410200. PMID 17686769.

Further reading

• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Mizuochi T, Matthews TJ, Kato M, et al. (1990). "Diversity of oligosaccharide structures on the envelope glycoprotein gp 120 of human immunodeficiency virus 1 from the lymphoblastoid cell line H9. Presence of complex-type oligosaccharides with bisecting N-acetylglucosamine residues". J. Biol. Chem. 265 (15): 8519–24. doi:10.1016/S0021-9258(19)38919-7. PMID 2341393.
• Shimizu H, Tsuchie H, Honma H, et al. (1990). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins". Jpn. J. Med. Sci. Biol. 43 (3): 75–87. doi:10.7883/yoken1952.43.75. PMID 2283726.
• Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry. 32 (41): 11087–99. doi:10.1021/bi00092a019. PMID 8218172.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Oh JH, Yang JO, Hahn Y, et al. (2005). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Epplen C, Epplen JT (1994). "Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes". Hum. Genet. 93 (1): 35–41. doi:10.1007/BF00218910. PMID 7505766. S2CID 22998633.
• Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
• Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.

External links

• Human ALG13 genome location and ALG13 gene details page in the UCSC Genome Browser.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome X
• Human proteins
• Human chromosome X gene stubs