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ARMCX6
Identifiers
Aliases	ARMCX6, GASP10, armadillo repeat containing, X-linked 6, armadillo repeat containing X-linked 6
External IDs	MGI: 2147993; HomoloGene: 10373; GeneCards: ARMCX6; OMA:ARMCX6 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq22.1 Start 101,615,118 bp End 101,618,001 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X E3 Start 133,649,210 bp End 133,652,166 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex body of pancreas left adrenal cortex smooth muscle tissue islet of Langerhans stromal cell of endometrium spleen monocyte right coronary artery lymph node Top expressed in ovary lens neural tube Mesencephalon epiblast genital tubercle Hypothalamus rhombencephalon neural layer of retina embryo More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 54470 278097 Ensembl ENSG00000198960 ENSMUSG00000050394 UniProt Q7L4S7 Q8K3A6 RefSeq (mRNA) NM_001009584 NM_001184768 NM_019007 NM_001007578 RefSeq (protein) NP_001009584 NP_001171697 NP_061880 NP_001007579 Location (UCSC) Chr X: 101.62 – 101.62 Mb Chr X: 133.65 – 133.65 Mb PubMed search
Wikidata
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Armadillo repeat containing X-linked 6 is a protein that in humans is encoded by the ARMCX6 gene located on the X-chromosome.

It is one of six armadillo repeats containing X-linked proteins (ARMCX1, ARMCX2, ARMCX3, ARMCX4, ARMCX5, and ARMCX6 (this protein)).

The function of this protein is unknown at this time.

Protein sequence

     1 MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE 
    41 GEEEWDDDQE LDEEEPDIWF DFETMARPWT EDGDWTEPGA 
    81 PGGTEDRPSG GGKANRAHPI KQRPFPYEHK NTWSAQNCKN 
   121 GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS QDINSHLASL 
   161 SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE 
   201 VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK 
   241 FPLISEGSGC AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS 
   301 FMSLFIRNGN REILLETPAP

Homology

ARMCX6 is conserved in many eukaryotic organisms.

Orthologs

Secondary Structure

The secondary structure of ARMCX6 is predicted to be similar to cyanase. A comparison of the two sequences is shown below.

                          10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
ARMCX6      231 MLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQM 277
1DW9_A       19 LLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKL 65
                 + +   ++ +  +  + + +   +   + +    +  +  ++++

Expression

Microarray data show that ARMCX6 is highly expressed during earliest stages of spermatogenesis in mice.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000198960 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000050394 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: armadillo repeat containing".
6. SDSC Biology Workbench 2.0
7. "CBlast service is retiring".
8. EST Profile Viewer- Human
9. EST Profile Viewer- Mouse
10. Su AI, Wiltshire T, Batalov S, Lapp H, et al. (April 2004). "A gene atlas of the mouse and human protein-encoding transcriptomes". Proceedings of the National Academy of Sciences of the United States of America. 101 (16): 6062–7. Bibcode:2004PNAS..101.6062S. doi:10.1073/pnas.0400782101. PMC 395923. PMID 15075390.

External links

• Human ARMCX6 genome location and ARMCX6 gene details page in the UCSC Genome Browser.

Further reading

• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

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• Genes on human chromosome X
• Human chromosome X gene stubs
• Armadillo-repeat-containing proteins