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ASAH2B
Identifiers
Aliases	ASAH2B, ASAH2L, bA449O16.3, bA98I6.3, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B, ASAH2C, N-acylsphingosine amidohydrolase 2B
External IDs	GeneCards: ASAH2B; OMA:ASAH2B - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q11.23 Start 50,739,318 bp End 50,816,495 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum gonad islet of Langerhans ganglionic eminence testicle superior frontal gyrus liver primary visual cortex rectum ventricular zone n/a More reference expression data BioGPS n/a
Gene ontology Molecular function N-acylsphingosine amidohydrolase activity Cellular component extracellular region Biological process long-chain fatty acid biosynthetic process sphingosine biosynthetic process ceramide catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 653308 n/a Ensembl ENSG00000204147 n/a UniProt P0C7U1 n/a RefSeq (mRNA) NM_001079516 NM_001321957 NM_001321958 NM_001321959 NM_001321960 n/a RefSeq (protein) NP_001072984 NP_001308886 NP_001308887 NP_001308888 NP_001308889 n/a Location (UCSC) Chr 10: 50.74 – 50.82 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene.

Clinical significance

ASAH2B shows reduced expression with increasing age and further reduction in late onset Alzheimer's disease patients.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000204147 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS (April 2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics. 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805. S2CID 20156514.
4. Deloukas P, Earthrowl ME, Grafham DV, et al. (May 2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.

External links

• Human ASAH2B genome location and ASAH2B gene details page in the UCSC Genome Browser.

Further reading

• Brandenberger R, Wei H, Zhang S, et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.

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