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Acetoacetyl-CoA hydrolase

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Class of enzymes
acetoacetyl-CoA hydrolase
Identifiers
EC no.3.1.2.11
CAS no.37288-10-1
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The enzyme acetoacetyl-CoA hydrolase (EC 3.1.2.11) catalyzes the reaction

acetoacetyl-CoA + H2O {\displaystyle \rightleftharpoons } CoA + acetoacetate

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is acetoacetyl-CoA hydrolase. Other names in common use include acetoacetyl coenzyme A hydrolase, acetoacetyl CoA deacylase, and acetoacetyl coenzyme A deacylase. This enzyme participates in butanoate metabolism.

References

  • Aragon JJ, Lowenstein JM (1983). "A survey of enzymes which generate or use acetoacetyl thioesters in rat liver". J. Biol. Chem. 258 (8): 4725–33. PMID 6131897.
  • Drummond GI, Stern JR (1960). "Enzymes of ketone body metabolism. II. Properties of an acetoacetate-synthesizing enzyme prepared from ox liver". J. Biol. Chem. 235: 318–25. PMID 13818236.
Hydrolase: esterases (EC 3.1)
3.1.1: Carboxylic
ester hydrolases
3.1.2: Thioesterase
3.1.3: Phosphatase
3.1.4:
Phosphodiesterase
3.1.6: Sulfatase
Nuclease (includes
deoxyribonuclease
and ribonuclease)
3.1.11-16:
Exonuclease
Exodeoxyribonuclease
Exoribonuclease
3.1.21-31:
Endonuclease
Endodeoxyribonuclease
Endoribonuclease
either deoxy- or ribo-    
Enzymes
Activity
Regulation
Classification
Kinetics
Types
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