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In enzymology, an acetylacetone-cleaving enzyme (EC 1.13.11.50) is an enzyme that catalyzes the chemical reaction

pentane-2,4-dione + O₂ ${\displaystyle \rightleftharpoons }$ acetate + 2-oxopropanal

Thus, the two substrates of this enzyme are pentane-2,4-dione and O₂, whereas its two products are acetate and 2-oxopropanal.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is acetylacetone:oxygen oxidoreductase. Other names in common use include Dke1, acetylacetone dioxygenase, diketone cleaving dioxygenase, and diketone cleaving enzyme.

References

• Straganz GD, Glieder A, Brecker L, Ribbons DW, Steiner W (2003). "Acetylacetone-cleaving enzyme Dke1: a novel C-C-bond-cleaving enzyme from Acinetobacter johnsonii". Biochem. J. 369 (Pt 3): 573–81. doi:10.1042/BJ20021047. PMC 1223103. PMID 12379146.

• Biology

• EC 1.13.11
• Enzymes of unknown structure