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Aganodine

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Aganodine
Names
IUPAC name 2-(4,7-Dichloro-1,3-dihydroisoindol-2-yl)guanidine
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C9H10Cl2N4/c10-7-1-2-8(11)6-4-15(3-5(6)7)14-9(12)13/h1-2H,3-4H2,(H4,12,13,14)Key: DFKHOVYSCCPSHR-UHFFFAOYSA-N
SMILES
  • C1C2=C(C=CC(=C2CN1N=C(N)N)Cl)Cl
Properties
Chemical formula C9H10Cl2N4
Molar mass 245.109
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound
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Aganodine is a guanidine that activates presynaptic imidazoline receptors. Through its agonism at imidazoline receptors, aganodine inhibits the presynaptic release of norepinephrine.

References

  1. Molderings, GJ; Likungu, J; Jakschik, J; Göthert, M (1997). "Presynaptic imidazoline receptors and non-adrenoceptor 3H-idazoxan binding sites in human cardiovascular tissues". British Journal of Pharmacology. 122 (1): 43–50. doi:10.1038/sj.bjp.0701343. PMC 1564902. PMID 9298527.
  2. Göthert, M.; Brüss, M.; Bönisch, H.; Molderings, G.J. (1999). "Presynaptic Imidazoline Receptors". Annals of the New York Academy of Sciences. 881: 171–184. doi:10.1111/j.1749-6632.1999.tb09356.x. PMID 10415912. S2CID 12242403.


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