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All-trans-phytoene synthase (EC 2.5.1.99, prephytoene-diphosphate synthase, phytoene synthetase, PSase, geranylgeranyl-diphosphate geranylgeranyltransferase, 15-trans-phytoene synthase) is an enzyme with systematic name geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase (all-trans-phytoene forming). This enzyme catalyses the following chemical reaction

2 geranylgeranyl diphosphate ${\displaystyle \rightleftharpoons }$ all-trans-phytoene + 2 diphosphate (overall reaction)

(1a) 2 geranylgeranyl diphosphate ${\displaystyle \rightleftharpoons }$ diphosphate + prephytoene diphosphate

(1b) prephytoene diphosphate ${\displaystyle \rightleftharpoons }$ all-trans-phytoene + diphosphate

This enzyme requires Mn for activity.

References

1. Gregonis DE, Rilling HC (March 1974). "The stereochemistry of trans-phytoene synthesis. Some observations on lycopersene as a carotene precursor and a mechanism for the synthesis of cis- and trans-phytoene". Biochemistry. 13 (7): 1538–42. doi:10.1021/bi00704a033. PMID 4819767.
2. Iwata-Reuyl D, Math SK, Desai SB, Poulter CD (March 2003). "Bacterial phytoene synthase: molecular cloning, expression, and characterization of Erwinia herbicola phytoene synthase". Biochemistry. 42 (11): 3359–65. doi:10.1021/bi0206614. PMID 12641468.

External links

• All-trans-phytoene+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 2.5.1