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AMBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BIK, 3QKG, 4ES7, 4U30
Identifiers
Aliases	AMBP, A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI, alpha-1-microglobulin/bikunin precursor
External IDs	OMIM: 176870; MGI: 88002; HomoloGene: 1234; GeneCards: AMBP; OMA:AMBP - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q32 Start 114,060,127 bp End 114,078,328 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 B3|4 33.96 cM Start 63,061,512 bp End 63,073,036 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver gallbladder body of pancreas islet of Langerhans testicle oocyte pancreatic epithelial cell secondary oocyte human kidney gonad Top expressed in left lobe of liver gallbladder fetal liver hematopoietic progenitor cell yolk sac human fetus abdominal wall right lobe of liver islet of Langerhans embryo sexually immature organism More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity calcium channel inhibitor activity protein homodimerization activity calcium oxalate binding protein binding heme binding serine-type endopeptidase inhibitor activity small molecule binding IgA binding Cellular component blood microparticle intracellular membrane-bounded organelle plasma membrane extracellular region cell surface extracellular exosome extracellular space extracellular matrix collagen-containing extracellular matrix Biological process negative regulation of peptidase activity female pregnancy receptor-mediated endocytosis negative regulation of JNK cascade heme catabolic process negative regulation of immune response cell adhesion protein catabolic process viral process negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 259 11699 Ensembl ENSG00000106927 ENSMUSG00000028356 UniProt P02760 Q07456 RefSeq (mRNA) NM_001633 NM_007443 RefSeq (protein) NP_001624 NP_031469 Location (UCSC) Chr 9: 114.06 – 114.08 Mb Chr 4: 63.06 – 63.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Protein AMBP is a protein that in humans is encoded by the AMBP gene.

Interactions

Alpha-1-microglobulin/bikunin precursor has been shown to interact with CD79A.

See also

• Inter-alpha-trypsin inhibitor
• Alpha-1-microglobulin

References

1. ^ GRCh38: Ensembl release 89: ENSG00000106927 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028356 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vetr H, Gebhard W (1990). "Structure of the human alpha 1-microglobulin-bikunin gene". Biol. Chem. Hoppe-Seyler. 371 (12): 1185–96. doi:10.1515/bchm3.1990.371.2.1185. PMID 1708673.
6. Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
7. "Entrez Gene: AMBP alpha-1-microglobulin/bikunin precursor".
8. Grubb AO, López C, Tejler L, Mendez E (December 1983). "Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration". J. Biol. Chem. 258 (23): 14698–707. doi:10.1016/S0021-9258(17)43919-6. PMID 6196366.
9. Berggård T, Thelin N, Falkenberg C, Enghild JJ, Akerström B (May 1997). "Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma". Eur. J. Biochem. 245 (3): 676–83. doi:10.1111/j.1432-1033.1997.00676.x. PMID 9183005.

Further reading

• Akerström B, Lögdberg L, Berggård T, Osmark P, Lindqvist A (2000). "alpha(1)-Microglobulin: a yellow-brown lipocalin". Biochim. Biophys. Acta. 1482 (1–2): 172–84. doi:10.1016/S0167-4838(00)00157-6. PMID 11058759.
• Kobayashi H, Suzuki M, Hirashima Y, Terao T (2003). "The protease inhibitor bikunin, a novel anti-metastatic agent". Biol. Chem. 384 (5): 749–54. doi:10.1515/BC.2003.083. PMID 12817471. S2CID 38608465.
• Ekström B, Berggård I (1977). "Human alpha1-microglobulin. Purification procedure, chemical and physiochemical properties". J. Biol. Chem. 252 (22): 8048–57. doi:10.1016/S0021-9258(17)40934-3. PMID 72071.
• Escribano J, Lopex-Otin C, Hjerpe A, Grubb A, Mendez E (1990). "Location and characterization of the three carbohydrate prosthetic groups of human protein HC". FEBS Lett. 266 (1–2): 167–70. doi:10.1016/0014-5793(90)81531-R. PMID 1694784. S2CID 36320110.
• Diarra-Mehrpour M, Bourguignon J, Sesboüé R, Salier JP, Léveillard T, Martin JP (1990). "Structural analysis of the human inter-alpha-trypsin inhibitor light-chain gene". Eur. J. Biochem. 191 (1): 131–9. doi:10.1111/j.1432-1033.1990.tb19102.x. PMID 1696200.
• Gebhard W, Schreitmüller T, Vetr H, Wachter E, Hochstrasser K (1990). "Complementary DNA and deduced amino acid sequences of procine alpha 1-microglobulin and bikunin". FEBS Lett. 269 (1): 32–6. doi:10.1016/0014-5793(90)81112-2. PMID 1696914. S2CID 84271910.
• Falkenberg C, Grubb A, Akerström B (1990). "Isolation of rat serum alpha 1-microglobulin. Identification of a complex with alpha 1-inhibitor-3, a rat alpha 2-macroglobulin homologue". J. Biol. Chem. 265 (27): 16150–7. doi:10.1016/S0021-9258(17)46201-6. PMID 1697852.
• Nazimova SV, Akulenko IV, Zaĭtseva IV, Zaraĭskiĭ EI, Posiseeva LV (1990). "". Akush Ginekol (Mosk) (7): 70–2. PMID 1700638.
• Escribano J, Grubb A, Calero M, Méndez E (1991). "The protein HC chromophore is linked to the cysteine residue at position 34 of the polypeptide chain by a reduction-resistant bond and causes the charge heterogeneity of protein HC". J. Biol. Chem. 266 (24): 15758–63. doi:10.1016/S0021-9258(18)98474-7. PMID 1714898.
• Enghild JJ, Salvesen G, Hefta SA, Thøgersen IB, Rutherfurd S, Pizzo SV (1991). "Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor". J. Biol. Chem. 266 (2): 747–51. doi:10.1016/S0021-9258(17)35235-3. PMID 1898736.
• Reisinger P, Hochstrasser K, Albrecht GJ, Lempart K, Salier JP (1985). "Human inter-alpha-trypsin inhibitor: localization of the Kunitz-type domains in the N-terminal part of the molecule and their release by a trypsin-like proteinase". Biol. Chem. Hoppe-Seyler. 366 (5): 479–83. doi:10.1515/bchm3.1985.366.1.479. PMID 2408638.
• Bourguignon J, Diarra-Mehrpour M, Sesboüé R, Frain M, Sala-Trepat JM, Martin JP, Salier JP (1985). "Human inter-alpha-trypsin-inhibitor: characterization and partial nucleotide sequencing of a light chain-encoding cDNA". Biochem. Biophys. Res. Commun. 131 (3): 1146–53. doi:10.1016/0006-291X(85)90210-4. PMID 2413856.
• Méndez E, Fernández-Luna JL, Grubb A, Leyva-Cobián F (1986). "Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis". Proc. Natl. Acad. Sci. U.S.A. 83 (5): 1472–5. Bibcode:1986PNAS...83.1472M. doi:10.1073/pnas.83.5.1472. PMC 323098. PMID 2419908.
• Traboni C, Cortese R (1986). "Sequence of a full length cDNA coding for human protein HC (alpha 1 microglobulin)". Nucleic Acids Res. 14 (15): 6340. doi:10.1093/nar/14.15.6340. PMC 311643. PMID 2428011.
• Kaumeyer JF, Polazzi JO, Kotick MP (1986). "The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin (protein HC)". Nucleic Acids Res. 14 (20): 7839–50. doi:10.1093/nar/14.20.7839. PMC 311818. PMID 2430261.
• Zaraĭskiĭ EI, Nazimova SV, Olefirenko GA, Pchelkina ZM, Petrunin DD, Tatarinov IuS, Fuks BB (1990). "". Vopr. Med. Khim. 35 (5): 130–2. PMID 2482577.
• Schreitmüller T, Hochstrasser K, Reisinger PW, Wachter E, Gebhard W (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins". Biol. Chem. Hoppe-Seyler. 368 (8): 963–70. doi:10.1515/bchm3.1987.368.2.963. PMID 3663330.
• Morii M, Travis J (1985). "The reactive site of human inter-alpha-trypsin inhibitor is in the amino-terminal half of the protein". Biol. Chem. Hoppe-Seyler. 366 (1): 19–21. doi:10.1515/bchm3.1985.366.1.19. PMID 3890890.

External links

• The MEROPS online database for peptidases and their inhibitors: LI02-001

This article on a gene on human chromosome 9 is a stub. You can help Misplaced Pages by expanding it.

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• Genes on human chromosome 9
• Precursor proteins
• Lipocalins
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