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Amidrine

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Combination drug

Amidrine, Midrin, Nodolor, Duradrin, IDA, Migquin, Migrin-A, Migrazone or Epidrine is a combination drug consisting of paracetamol, dichloralphenazone and isometheptene used to treat migraines and severe, refractory headaches.

Components

Availability

Midrin was discontinued by Caraco Pharmaceuticals as of 2009, after an FDA seizure of 33 drugs manufactured by Caraco Pharmaceuticals due to cGMP (Current Good Manufacturing Practices) violations. Generic forms of Amidrine were also discontinued due to loss of FDA grandfather approval status. Thus, manufacturer interest faded. The discontinued generic forms are: Amidrine (Actavis), Duradrin (Barr), I.D.A (Teva), Migquin (Qualitest), Migrin-A (Prasco) and Migrazone (Breckenridge). However, it is now being manufactured by Macoven Pharmaceuticals and marketed under the name Nodolor, as of April 2014. It can also be obtained through a compounding pharmacy with a doctor's prescription.

References

  1. Freitag, Frederick G.; Cady, Roger; DiSerio, Frank (20 Dec 2001). "Comparative Study of a Combination of Isometheptene Mucate, Dichloralphenazone With Acetaminophen and Sumatriptan Succinate in the Treatment of Migraine". Headache. 41 (4): 391–8. doi:10.1046/j.1526-4610.2001.111006391.x. PMID 11318886. S2CID 35970757.
  2. "Questions and Answers: Seizure of Drug Products Manufactured by Caraco Pharmaceutical Laboratories Ltd". Food and Drug Administration.
  3. "Drug Profiles: MIDRIN®".
Antimigraine preparations (N02C)
Analgesic/abortive
Serotonergics
Ergolines
5-HT1 agonists
Triptans
Ditans
Others
CGRP-R antagonists
Others
Prophylactic
Calcium channel blockers
Progestogens
Sympatholytics
Tricyclic antidepressants
Anticonvulsants
Anti-CGRP/CGRP-R mAbs
CGRP-R antagonists


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