An anti-LKM antibody (anti–liver-kidney microsomal antibody or LKM antibody) is any of several autoantibodies that are detected in the serum of patients with different types of acute or chronic liver disease. These antibodies are targeted against antigens of the cytochrome P450 system.
Classification
There are three kinds of anti-LKM antibodies:
| Microsomal antibody | Antigen | Disease |
|---|---|---|
| anti-LKM 1 | cytochrome P450 2D6 | autoimmune hepatitis type II and chronic hepatitis C (10%) |
| anti-LKM 2 | cytochrome P450 2C9 | drug-induced hepatitis (tienilic acid–induced) |
| anti-LKM 3 | cytochrome P450 1A2 | chronic active hepatitis in association with autoimmune polyendocrine syndrome type 1; hepatitis D |
References
- Gebre-Medhin G et al., FEBS Letters 1997
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