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B3GNT2
Identifiers
Aliases	B3GNT2, B3GN-T2, B3GNT, B3GNT-2, B3GNT1, BETA3GNT, BGNT2, BGnT-2, 3-Gn-T1, 3-Gn-T2, beta-1, beta3Gn-T1, beta3Gn-T2, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
External IDs	OMIM: 605581; MGI: 1889505; HomoloGene: 4797; GeneCards: B3GNT2; OMA:B3GNT2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p15 Start 62,196,115 bp End 62,224,731 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 A3.2|11 14.22 cM Start 22,709,738 bp End 22,810,961 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte visceral pleura epithelium of nasopharynx germinal epithelium lower lobe of lung parietal pleura mucosa of paranasal sinus jejunal mucosa mucosa of sigmoid colon gingival epithelium Top expressed in primary oocyte secondary oocyte granulocyte zygote striatum of neuraxis adrenal gland genital tubercle proximal tubule right kidney tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity glycosyltransferase activity galactosyltransferase activity N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity acetylgalactosaminyltransferase activity protein binding Cellular component integral component of membrane Golgi apparatus membrane Golgi membrane endoplasmic reticulum Biological process poly-N-acetyllactosamine biosynthetic process axon guidance protein glycosylation sensory perception of smell O-glycan processing keratan sulfate biosynthetic process cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10678 53625 Ensembl ENSG00000170340 ENSMUSG00000051650 UniProt Q9NY97 Q9Z222 RefSeq (mRNA) NM_006577 NM_033252 NM_001319075 NM_018554 NM_001169114 NM_016888 RefSeq (protein) NP_001306004 NP_006568 NP_001162585 NP_058584 Location (UCSC) Chr 2: 62.2 – 62.22 Mb Chr 11: 22.71 – 22.81 Mb PubMed search
Wikidata
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UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 is an enzyme that in humans is encoded by the B3GNT2 gene.

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000170340 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000051650 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhou D, Dinter A, Gutierrez Gallego R, Kamerling JP, Vliegenthart JF, Berger EG, Hennet T (Mar 1999). "A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases". Proc Natl Acad Sci U S A. 96 (2): 406–11. Bibcode:1999PNAS...96..406Z. doi:10.1073/pnas.96.2.406. PMC 15149. PMID 9892646.
6. Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K (May 2001). "Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family". J Biol Chem. 276 (5): 3498–507. doi:10.1074/jbc.M004800200. PMID 11042166.
7. ^ "Entrez Gene: B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2".

External links

• Human B3GNT2 genome location and B3GNT2 gene details page in the UCSC Genome Browser.

Further reading

• Amado M, Almeida R, Schwientek T, Clausen H (2000). "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions". Biochim. Biophys. Acta. 1473 (1): 35–53. doi:10.1016/S0304-4165(99)00168-3. PMID 10580128.
• Ju T, Cummings RD (2003). "A unique molecular chaperone Cosmc required for activity of the mammalian core 1 β3-galactosyltransferase". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16613–8. doi:10.1073/pnas.262438199. PMC 139192. PMID 12464682.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Isshiki S, Kudo T, Nishihara S, et al. (2003). "Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins". J. Biol. Chem. 278 (38): 36611–20. doi:10.1074/jbc.M302681200. PMID 12855703.
• Hayashi N, Nakamori S, Okami J, et al. (2004). "Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue". Pathobiology. 71 (1): 26–34. doi:10.1159/000072959. PMID 14555842. S2CID 11013021.
• Mare L, Trinchera M (2004). "Suppression of beta 1,3galactosyltransferase beta 3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans". Eur. J. Biochem. 271 (1): 186–194. doi:10.1046/j.1432-1033.2003.03919.x. PMID 14686931. S2CID 38965439.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zheng H, Li Y, Ji C, et al. (2005). "Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase". Mol. Biol. Rep. 31 (3): 171–5. doi:10.1023/B:MOLE.0000043552.32411.67. PMID 15560372. S2CID 22952647.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

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