Misplaced Pages

BIIB131

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
This article is an orphan, as no other articles link to it. Please introduce links to this page from related articles; try the Find link tool for suggestions. (March 2024)
BIIB131
Names
IUPAC name (2S)-2,5-bis-3,5-dihydroxy-2-methyl-7-oxo-4,9-dihydro-3H-pyranoisoindol-8-yl]pentanoic acid
Other names
    • SMTP-7
    • TMS-007
Identifiers
3D model (JSmol)
PubChem CID
InChI
  • InChI=1S/C51H68N2O10/c1-30(2)14-9-16-32(5)18-11-21-50(7)43(56)26-36-41(54)24-34-38(45(36)62-50)28-52(47(34)58)23-13-20-40(49(60)61)53-29-39-35(48(53)59)25-42(55)37-27-44(57)51(8,63-46(37)39)22-12-19-33(6)17-10-15-31(3)4/h14-15,18-19,24-25,40,43-44,54-57H,9-13,16-17,20-23,26-29H2,1-8H3,(H,60,61)/b32-18+,33-19+/t40-,43-,44-,50-,51-/m0/s1Key: CRNDCHORWGDFGR-PXTWCNKMSA-N
SMILES
  • CC(=CCC/C(=C/CC1((CC2=C(C=C3C(=C2O1)CN(C3=O)CCC(C(=O)O)N4CC5=C6C(=C(C=C5C4=O)O)C((O6)(C)CC/C=C(\C)/CCC=C(C)C)O)O)O)C)/C)C
Properties
Chemical formula C51H68N2O10
Molar mass 869.109 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

BIIB131 (also known as SMTP-7 or TMS-007) is a prothrombolytic small-molecule drug developed by Biogen for acute ischemic stroke.

References

  1. Yuan, Long; Jiang, Di; Pinkham, Andrew; Kirkland, Melissa (November 2023). "Development, validation and application of a capillary microsampling LC–MS/MS method for the quantification of BIIB131 (SMTP-7) in rat plasma". Journal of Pharmaceutical and Biomedical Analysis. 236: 115752. doi:10.1016/j.jpba.2023.115752. PMID 37769527.
  2. Kostrubsky, Vick; Liu, Ying; Muste, Cathy; Gu, Chungang; Kirkland, Melissa; Nishimura, Naoko; Hasegawa, Keiko; Hasumi, Keiji; Yuan, Long (December 2023). "Preclinical safety, toxicokinetics and metabolism of BIIB131, a novel prothrombolytic agent for acute stroke". Regulatory Toxicology and Pharmacology. 145: 105498. doi:10.1016/j.yrtph.2023.105498. PMID 37778433. S2CID 263297651.
  3. Wang, Bo; Lin, Yiqing (2022). "Absolute configuration determination of SMTP-7 via microcrystal electron diffraction (MicroED)". Chemical Communications. 58 (94): 13071–13074. doi:10.1039/D2CC05218K. PMID 36305866. S2CID 253184088.
Categories: