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BTAF1
Identifiers
Aliases	BTAF1, MOT1, TAF(II)170, TAF172, TAFII170, B-TFIID TATA-box binding protein associated factor 1
External IDs	OMIM: 605191; MGI: 2147538; HomoloGene: 31978; GeneCards: BTAF1; OMA:BTAF1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q23.32 Start 91,923,770 bp End 92,030,325 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 C2 Start 36,903,479 bp End 36,990,152 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell germinal epithelium hair follicle Achilles tendon cartilage tissue epithelium of nasopharynx pancreatic epithelial cell gastric mucosa tibia skin of arm Top expressed in hand seminiferous tubule condyle spermatocyte fossa medullary collecting duct primitive streak epidermis abdominal wall hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding nucleotide binding hydrolase activity ATP binding helicase activity protein binding Cellular component intracellular membrane-bounded organelle nucleus nucleoplasm Biological process negative regulation of transcription, DNA-templated negative regulation of chromatin binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9044 107182 Ensembl ENSG00000095564 ENSMUSG00000040565 UniProt O14981 Q2M1V9 E9QAE3 RefSeq (mRNA) NM_003972 NM_001080706 RefSeq (protein) NP_003963 NP_003963.1 NP_001074175 Location (UCSC) Chr 10: 91.92 – 92.03 Mb Chr 19: 36.9 – 36.99 Mb PubMed search
Wikidata
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TATA-binding protein-associated factor 172 is a protein that in humans is encoded by the BTAF1 gene.

Function

Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP; MIM 600075) and TBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.

Interactions

BTAF1 has been shown to interact with TATA binding protein.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000095564 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000040565 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. van der Knaap JA, Borst JW, van der Vliet PC, Gentz R, Timmers HT (Dec 1997). "Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila". Proc Natl Acad Sci U S A. 94 (22): 11827–32. Bibcode:1997PNAS...9411827V. doi:10.1073/pnas.94.22.11827. PMC 23617. PMID 9342322.
6. ^ Chicca JJ, Auble DT, Pugh BF (Mar 1998). "Cloning and Biochemical Characterization of TAF-172, a Human Homolog of Yeast Mot1". Mol Cell Biol. 18 (3): 1701–10. doi:10.1128/MCB.18.3.1701. PMC 108885. PMID 9488487.
7. ^ "Entrez Gene: BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)".
8. Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.

External links

• Human BTAF1 genome location and BTAF1 gene details page in the UCSC Genome Browser.

Further reading

• Zhou Q, Sharp PA (1995). "Novel mechanism and factor for regulation by HIV-1 Tat". EMBO J. 14 (2): 321–8. doi:10.1002/j.1460-2075.1995.tb07006.x. PMC 398086. PMID 7835343.
• Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro". J. Biol. Chem. 270 (5): 2274–83. doi:10.1074/jbc.270.5.2274. PMID 7836461.
• Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB (1994). "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188–99. doi:10.1128/JVI.68.11.7188-7199.1994. PMC 237158. PMID 7933101.
• Kashanchi F, Piras G, Radonovich MF, Duvall JF, Fattaey A, Chiang CM, Roeder RG, Brady JN (1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295–9. Bibcode:1994Natur.367..295K. doi:10.1038/367295a0. PMID 8121496. S2CID 4362048.
• Wang Z, Morris GF, Rice AP, Xiong W, Morris CB (1996). "Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (2): 128–38. doi:10.1097/00042560-199606010-00005. PMID 8680883.
• Pendergrast PS, Morrison D, Tansey WP, Hernandez N (1996). "Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly". J. Virol. 70 (8): 5025–34. doi:10.1128/JVI.70.8.5025-5034.1996. PMC 190456. PMID 8764009.
• Kashanchi F, Khleif SN, Duvall JF, Sadaie MR, Radonovich MF, Cho M, Martin MA, Chen SY, Weinmann R, Brady JN (1996). "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex". J. Virol. 70 (8): 5503–10. doi:10.1128/JVI.70.8.5503-5510.1996. PMC 190508. PMID 8764062.
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
• García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. doi:10.1074/jbc.272.11.6951. PMID 9054383.
• Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
• Van Der Knaap JA, Van Den Boom V, Kuipers J, Van Eijk MJ, Van Der Vliet PC, Timmers HT (2000). "The gene for human TATA-binding-protein-associated factor (TAFII) 170: structure, promoter and chromosomal localization". Biochem. J. 345 (3): 521–7. doi:10.1042/0264-6021:3450521. PMC 1220786. PMID 10642510.
• Wadhwa R, Yaguchi T, Hasan MK, Taira K, Kaul SC (2003). "Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation". Biochem. Biophys. Res. Commun. 302 (4): 735–42. doi:10.1016/S0006-291X(03)00226-2. PMID 12646231.
• Pereira LA, Klejman MP, Ruhlmann C, Kavelaars F, Oulad-Abdelghani M, Timmers HT, Schultz P (2004). "Molecular architecture of the basal transcription factor B-TFIID". J. Biol. Chem. 279 (21): 21802–7. doi:10.1074/jbc.M313519200. PMID 14988402.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Klejman MP, Pereira LA, van Zeeburg HJ, Gilfillan S, Meisterernst M, Timmers HT (2004). "NC2α Interacts with BTAF1 and Stimulates Its ATP-Dependent Association with TATA-Binding Protein". Mol. Cell. Biol. 24 (22): 10072–82. doi:10.1128/MCB.24.22.10072-10082.2004. PMC 525489. PMID 15509807.
• Grob P, Cruse MJ, Inouye C, Peris M, Penczek PA, Tjian R, Nogales E (2006). "Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues". Structure. 14 (3): 511–20. doi:10.1016/j.str.2005.11.020. PMID 16531235.

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