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BYSL
Identifiers
Aliases	BYSL, BYSTIN, bystin like, Enp1
External IDs	OMIM: 603871; MGI: 1858419; HomoloGene: 2991; GeneCards: BYSL; OMA:BYSL - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.1 Start 41,921,499 bp End 41,933,046 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 C|17 23.63 cM Start 47,910,256 bp End 47,922,417 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad gastrocnemius muscle testicle islet of Langerhans embryo ganglionic eminence right adrenal gland stromal cell of endometrium left adrenal gland right adrenal cortex Top expressed in otic placode saccule otic vesicle cardiac muscle tissue of left ventricle fetal liver hematopoietic progenitor cell Ileal epithelium somite endothelial cell of lymphatic vessel primitive streak epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding snoRNA binding Cellular component cytoplasm membrane intracellular membrane-bounded organelle apical part of cell nucleolus nucleus cytosol nucleoplasm preribosome, small subunit precursor Biological process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosome biogenesis female pregnancy in utero embryonic development blastocyst formation cell adhesion trophectodermal cell differentiation cell population proliferation rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 705 53414 Ensembl ENSG00000112578 ENSMUSG00000023988 UniProt Q13895 O54825 RefSeq (mRNA) NM_004053 NM_016859 RefSeq (protein) NP_004044 NP_058555 Location (UCSC) Chr 6: 41.92 – 41.93 Mb Chr 17: 47.91 – 47.92 Mb PubMed search
Wikidata
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Bystin is a protein that in humans is encoded by the BYSL gene.

Function

Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi.

Interactions

BYSL has been shown to interact with TROAP.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000112578 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000023988 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pack SD, Pak E, Tanigami A, Ledbetter DH, Fukuda MN (Mar 1999). "Assignment1 of the bystin gene BYSL to human chromosome band 6p21.1 by in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 76–7. doi:10.1159/000015131. PMID 9925933. S2CID 33756326.
6. Miyoshi M, Okajima T, Matsuda T, Fukuda MN, Nadano D (May 2007). "Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis". Biochem J. 404 (3): 373–81. doi:10.1042/BJ20061597. PMC 1896285. PMID 17381424.
7. ^ "Entrez Gene: BYSL bystin-like".
8. Suzuki N, Zara J, Sato T, Ong E, Bakhiet N, Oshima RG, Watson KL, Fukuda MN (Apr 1998). "A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5027–32. Bibcode:1998PNAS...95.5027S. doi:10.1073/pnas.95.9.5027. PMC 20207. PMID 9560222.

External links

• Human BYSL genome location and BYSL gene details page in the UCSC Genome Browser.

Further reading

• Suzuki N, Zara J, Sato T, Ong E, Bakhiet N, Oshima RG, Watson KL, Fukuda MN (1998). "A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5027–32. Bibcode:1998PNAS...95.5027S. doi:10.1073/pnas.95.9.5027. PMC 20207. PMID 9560222.
• Suzuki N, Nakayama J, Shih IM, Aoki D, Nozawa S, Fukuda MN (1999). "Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta". Biol. Reprod. 60 (3): 621–7. doi:10.1095/biolreprod60.3.621. PMID 10026108.
• Nakayama J, Aoki D, Suga T, Akama TO, Ishizone S, Yamaguchi H, Imakawa K, Nadano D, Fazleabas AT, Katsuyama T, Nozawa S, Fukuda MN (2004). "Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy". Am. J. Pathol. 163 (6): 2211–9. doi:10.1016/S0002-9440(10)63579-1. PMC 1892375. PMID 14633596.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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