Barbero is an Italian and Spanish surname. Notable people with the surname include:
- Aldo Barbero (1938–2013), Argentine actor
- Alessandro Barbero (born 1959), Italian historian
- Andrés Barbero (1877–1951), Paraguayan physician and philanthropist
- Gerardo Barbero (1961–2001), Argentine chess grandmaster
- Giuseppe Barbero (born 1927), Italian economist
- John Barbero (1945–2010), American public address announcer
- Lori Barbero (born 1961), American rock drummer
See also
- Barbera (disambiguation)
- Barberi, a surname
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