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BerEp4

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Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on a pathological section having BCC with squamous cell metaplasia. Only BCC cells are stained with BerEP4.
Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on superficial BCC pathological sections mimicking Bowen’s Disease. At bottom, columnar epithelium in normal sweat glands stain positive too.

BerEp4 (also Ber-EP4) is a histologic stain mainly used to aid in the diagnosis of basal cell carcinoma (BCC). It is an antibody to EpCAM (epithelial cell adhesion molecule).

Clinical use

BerEp4 has a high sensitivity and specificity in being positive only in BCC cells. BerEp4 is normally negative in squamous epithelium and mesothelium, but otherwise normally positive most epithelial cells of the body. It can also help in distinguishing pulmonary adenocarcinoma (positive BerEp4) from mesothelioma (generally negative BerEp4).

See also

References

  1. ^ Sunjaya, Anthony Paulo; Sunjaya, Angela Felicia; Tan, Sukmawati Tansil (2017). "The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma". Journal of Skin Cancer. 2017: 1–10. doi:10.1155/2017/2692604. ISSN 2090-2905. PMC 5804366. PMID 29464122.
  2. "Ber-EP4". e-immunohistochemistry.info. Retrieved 24 May 2017.
  3. ^ "Test ID: BEREP - Ber-EP4 (Epithelial Cell Adhesion Molecule/EPCAM) Immunostain, Technical Component Only". Mayo Clinic Laboratories. Retrieved 2019-12-16.
  4. Ordóñez, Nelson G. (1998). "Value of the Ber-EP4 Antibody in Differentiating Epithelial Pleural Mesothelioma From Adenocarcinoma:The M.D. Anderson Experience and a Critical Review of the Literature". American Journal of Clinical Pathology. 109 (1): 85–89. doi:10.1093/ajcp/109.1.85. ISSN 0002-9173. PMID 9426522.
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