Big Butte may refer to:
- Big Butte Creek, tributary of the Rogue River in Oregon, United States
- Big Butte Springs, natural springs in Jackson County, Oregon, United States
- A fictitious town in Penn Zero: Part-Time Hero
- Big Butte (California), a mountain
- Big Butte (Nevada), a mountain
- Big Butte (Washington), a mountain
See also
- Big Butt Mountain (disambiguation), multiple summits in North Carolina, United States
- Big Southern Butte, lava domes in Idaho, United States
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