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Big Sister may refer to:

• An older sister, see birth order
• Big Sister (brothel), an online brothel in Prague
• "The Big Sister" (Dexter's Laboratory), an episode of Dexter's Laboratory
• "Big Sister," a song by Elvis Costello and the Attractions from Trust
• Big Sister's Island, one of the Sisters' Islands of Singapore
• Big Sisters, part of the Big Brothers, Big Sisters program
• Big Sister (radio), a United States radio soap opera
• Big Sister, an enemy type in the game BioShock 2
• Big Sis, a nickname for Secretary of Homeland Security Janet Napolitano
• The Big Sister (film), a lost 1916 American drama silent film
• Big Sister (foods), a brand of fruit cake and other baked goods in Australia

See also

• Grande Soeur (French: Big Sister), Seychelles; an island
• All pages with titles beginning with Big Sister
• All pages with titles containing Big Sisters
• All pages with titles containing Big Sister
• Big (disambiguation)
• Sister (disambiguation)
• Little Sister (disambiguation)
• Big Brother (disambiguation)

• Disambiguation pages