Buttle is a surname. Notable people with the surname include:
- Cecil Buttle (1906–1988), English cricketer
- Frank Buttle (1878–1953), English social worker
- Greg Buttle (born 1954), retired American football linebacker
- Jeffrey Buttle (born 1982), Canadian figure skater
- Keith Buttle (1900–1973), New Zealand businessman and politician
- Robert D. Buttle (died 1901), the sole Brooklyn survivor of the Marine battalion which took part in the Mexican–American War
- Steve Buttle (1953–2012), English footballer and manager
Fictional characters:
- Buttle family, characters from the 1985 film Brazil
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