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CCDC90B

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Protein-coding gene in humans
CCDC90B
Identifiers
AliasesCCDC90B, MDS011, MDS025, coiled-coil domain containing 90B
External IDsMGI: 1913615; HomoloGene: 23328; GeneCards: CCDC90B; OMA:CCDC90B - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)
Chromosome 11 (human)Genomic location for CCDC90BGenomic location for CCDC90B
Band11q14.1Start83,259,081 bp
End83,286,390 bp
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)
Chromosome 7 (mouse)Genomic location for CCDC90BGenomic location for CCDC90B
Band7|7 E1Start92,210,357 bp
End92,231,502 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • ventricular zone

  • Achilles tendon

  • sperm

  • C1 segment

  • left testis

  • right testis

  • corpus callosum

  • right adrenal cortex

  • gonad
Top expressed in
  • atrioventricular valve

  • medial ganglionic eminence

  • vestibular membrane of cochlear duct

  • intercostal muscle

  • zygote

  • transitional epithelium of urinary bladder

  • vestibular sensory epithelium

  • epithelium of lens

  • endocardial cushion

  • secondary oocyte
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

60492

66365

Ensembl

ENSG00000137500

ENSMUSG00000030613

UniProt

Q9GZT6

Q8C3X2

RefSeq (mRNA)
NM_001286116
NM_001286117
NM_001286118
NM_001286119
NM_001286120

NM_021825

NM_001162918
NM_025515

RefSeq (protein)
NP_001273045
NP_001273046
NP_001273047
NP_001273048
NP_001273049

NP_068597

NP_001156390
NP_079791

Location (UCSC)Chr 11: 83.26 – 83.29 MbChr 7: 92.21 – 92.23 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Coiled coil domain containing 90B, also known as CCDC90B, is a protein encoded by the CCDC90B gene.

Gene

CCDC90B is located on chromosome 11 in humans. It is neighbored by:

  • PCF11, a mammalian pre-mRNA cleavage complex 2 protein
  • ANKRD42, ankyrin repeat protein involved with calcium ion bonding
  • BC070093
  • DLG2, a member of the membrane-associated guanylate kinase (MAGUK) family

Protein

Structure

This protein is characterized by the presence of a domain of unknown function, DUF1640. This domain is a characteristic of the entire protein with the exception of the first twenty-three amino acid residues - MNSRQAWRLFLSQGRGDRWVSRP - which are a mitochondrial targeting site and cleaved.

The protein has seven predicted alpha helices, a characteristic of coiled-coil proteins.

Predicted Properties

Molecular Weight: 26.72 kDa

Isoelectric point: 7.5

Transmembrane Helices: None

Post-translation modifications:

Chloroplast transit peptides: None
Signal pepties: None
C-mannosylation sites: None
N-glycosylation sites: None
Mitochondrial targeting: Yes
Cleaved site: MNSRQAWRLFLSQGRGDRWVSRP

Cellular Location

CCDC90B is presumably a mitochondrial protein. It is predicted to contain at least three specific phosphorylation sites: Protein Kinase C Phosphorylation sites, Casein Kinase II Phosphorylation sites, and cAMP/cGMP Dependent Phosphorylation sites.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000137500 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030613 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "UCSC Genome Bioinformatics BLAT". University of California - Santa Cruz. March 2006. Retrieved 2009-05-14.
  6. "ExPASy". SIB Switzerland. 2009-01-05. Retrieved 2009-05-14.

External links

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