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CMV polyradiculomyelopathy

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Medical condition
CMV polyradiculomyelopathy
SpecialtyNeurology

CMV polyradiculomyelopathy (PRAM) is one of the five distinct neurological syndromes caused by CMV in HIV/AIDS. It causes subacute ascending lower extremity weakness with paresthesias and radicular pain, hyporeflexia or areflexia, and urinary retention. It has been suggested that CMV polyradiculomyelopathy should be treated with both ganciclovir and foscarnet in patients who develop the disease while taking either of these drugs.

References

  1. Cohen, B. A.; McArthur, J. C.; Grohman, S.; Patterson, B.; Glass, J. D. (1 March 1993). "Neurologic prognosis of cytomegalovirus polyradiculomyelopathy in AIDS". Neurology. 43 (3, Part 1): 493–9. doi:10.1212/WNL.43.3_Part_1.493. PMID 8383823. S2CID 27051898.
  2. Guiot, HM; Pita-García, IL; Bertrán-Pasarell, J; Alfonso, G (December 2006). "Cytomegalovirus polyradiculomyelopathy in AIDS: a case report and review of the literature". Puerto Rico Health Sciences Journal. 25 (4): 359–62. PMID 17550105.
  3. Reiss, Carol (2008). Neurotropic Viral Infections. Cambridge University Press. p. 355. ISBN 9781139474160.


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