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COMPASS complex

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Protein complex

Complex Proteins Associated with Set1, also known as COMPASS, is a conserved protein complex playing a major role as a H3K4me3 methylase in eukaryotes. Since it was first identified in 2001, other members of the COMPASS family of methylases with different functions have been discovered, in particular in humans.

The COMPASS complex, or similar protein complexes, have been identified in species ranging from single-celled fungi to humans. They play an important regulatory role in many essential biological processes including DNA repair, the progression of the cell cycle, and transcription through the methylenation of histone lysines.

The COMPASS complex is an example of a trithorax-group protein. The MLL1/SET domain associated with the COMPASS complex have crystal structure. The gene Cps50 coordinates the construction of COMPASS.

References

  1. ^ Shilatifard, Ali (December 10, 2012). "The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis". Annual Review of Biochemistry. 81 (1): 65–95. doi:10.1146/annurev-biochem-051710-134100. PMC 4010150. PMID 22663077.
  2. Miller, Trissa; Krogan, Nevan J.; Dover, Jim; Erdjument-Bromage, H.; Tempst, Paul; Johnston, Mark; Greenblatt, Jack F.; Shilatifard, Ali (November 6, 2001). "COMPASS: A complex of proteins associated with a trithorax-related SET domain protein". Proceedings of the National Academy of Sciences. 98 (23): 12902–12907. Bibcode:2001PNAS...9812902M. doi:10.1073/pnas.231473398. PMC 60797. PMID 11687631.
  3. ^ Takahashi, Yoh-hei; Westfield, Gerwin H.; Oleskie, Austin N.; Trievel, Raymond C.; Shilatifard, Ali; Skiniotis, Georgios (2011-12-20). "Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human". Proceedings of the National Academy of Sciences. 108 (51): 20526–20531. Bibcode:2011PNAS..10820526T. doi:10.1073/pnas.1109360108. ISSN 0027-8424. PMC 3251153. PMID 22158900.
  4. Qu, Qianhui; Takahashi, Yoh-hei; Yang, Yidai; Hu, Hongli; Zhang, Yan; Brunzelle, Joseph S.; Couture, Jean-Francois; Shilatifard, Ali; Skiniotis, Georgios (2018-08-23). "Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex". Cell. 174 (5): 1117–1126.e12. doi:10.1016/j.cell.2018.07.020. ISSN 0092-8674. PMC 6108936. PMID 30100186.


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