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CORO1C
Identifiers
Aliases	CORO1C, HCRNN4, coronin 1C
External IDs	OMIM: 605269; MGI: 1345964; HomoloGene: 56537; GeneCards: CORO1C; OMA:CORO1C - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.11 Start 108,645,109 bp End 108,731,526 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 113,980,497 bp End 114,046,819 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein tendon of biceps brachii ganglionic eminence synovial joint Achilles tendon stromal cell of endometrium epithelium of colon urethra popliteal artery tibial arteries Top expressed in stroma of bone marrow corneal stroma ventricular zone yolk sac somite ileum epiblast intestinal villus ganglionic eminence crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin filament binding protein binding actin binding Cellular component cytoplasm vesicle cell projection lateral plasma membrane membrane focal adhesion plasma membrane flotillin complex actin cytoskeleton cytoskeleton lamellipodium Biological process regulation of protein phosphorylation negative regulation of protein phosphorylation positive regulation of lamellipodium morphogenesis activation of GTPase activity establishment of protein localization regulation of epithelial cell migration neural crest cell migration negative regulation of protein kinase activity by regulation of protein phosphorylation phagocytosis regulation of focal adhesion assembly regulation of ruffle assembly negative regulation of substrate adhesion-dependent cell spreading regulation of fibroblast migration regulation of substrate adhesion-dependent cell spreading negative regulation of focal adhesion assembly negative regulation of epithelial cell migration actin cytoskeleton organization signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23603 23790 Ensembl ENSG00000110880 ENSMUSG00000004530 UniProt Q9ULV4 Q9WUM4 RefSeq (mRNA) NM_001105237 NM_001276471 NM_014325 NM_011779 RefSeq (protein) NP_001098707 NP_001263400 NP_055140 NP_035909 Location (UCSC) Chr 12: 108.65 – 108.73 Mb Chr 5: 113.98 – 114.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Coronin-1C is a protein that in humans is encoded by the CORO1C gene.

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000110880 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000004530 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (Oct 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA Cell Biol. 17 (9): 779–87. doi:10.1089/dna.1998.17.779. PMID 9778037.
6. de Hostos EL (Oct 1999). "The coronin family of actin-associated proteins". Trends Cell Biol. 9 (9): 345–50. doi:10.1016/S0962-8924(99)01620-7. PMID 10461187.
7. ^ "Entrez Gene: CORO1C coronin, actin binding protein, 1C".

External links

• Human CORO1C genome location and CORO1C gene details page in the UCSC Genome Browser.

Further reading

• Rosentreter A, Hofmann A, Xavier CP, et al. (2007). "Coronin 3 involvement in F-actin-dependent processes at the cell cortex". Exp. Cell Res. 313 (5): 878–95. doi:10.1016/j.yexcr.2006.12.015. hdl:10072/14982. PMID 17274980.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Spoerl Z, Stumpf M, Noegel AA, Hasse A (2003). "Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus". J. Biol. Chem. 277 (50): 48858–67. doi:10.1074/jbc.M205136200. PMID 12377779.
• Iizaka M, Han HJ, Akashi H, et al. (2000). "Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins". Cytogenet. Cell Genet. 88 (3–4): 221–4. doi:10.1159/000015555. PMID 10828594. S2CID 46548464.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wick M, Bürger C, Brüsselbach S, et al. (1994). "Identification of serum-inducible genes: different patterns of gene regulation during G0-->S and G1-->S progression". J. Cell Sci. 107 (1): 227–39. doi:10.1242/jcs.107.1.227. PMID 8175911.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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