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Cadherin cytoplasmic region

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Protein family
Cadherin_C
beta-catenin/e-cadherin complex
Identifiers
SymbolCadherin_C
PfamPF01049
InterProIPR000233
SCOP21i7w / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology, the cadherin cytoplasmic region is a conserved region found at the C-terminus of cadherin proteins. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region (the part of the cytoplasmic region which is adjacent to the transmembrane domain) of the cadherin. This region induces clustering and also binds to the protein catenin (p120ctn). The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, possibly through interaction with the cytoskeleton.

See also

References

  1. Yap AS, Niessen CM, Gumbiner BM (May 1998). "The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn". J. Cell Biol. 141 (3): 779–89. doi:10.1083/jcb.141.3.779. PMC 2132752. PMID 9566976.
  2. Nagafuchi A, Takeichi M (December 1988). "Cell binding function of E-cadherin is regulated by the cytoplasmic domain". EMBO J. 7 (12): 3679–84. doi:10.1002/j.1460-2075.1988.tb03249.x. PMC 454940. PMID 3061804.
This article incorporates text from the public domain Pfam and InterPro: IPR000233

External links

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