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Caffeyville is an unincorporated community in Laclede County, Missouri, United States, along the former U.S. Route 66. It is located approximately five miles (8 km) southwest of Lebanon on Route W, adjacent to Interstate 44.

The community has the name of Jessie Floyd Caffey, the proprietor of a gas station.

References

1. U.S. Geological Survey Geographic Names Information System: Caffeyville, Missouri
2. Missouri Atlas & Gazetteer, DeLorme, 1998, First edition, p. 53, ISBN 0-89933-224-2
3. Sonderman, Joe (2009). Route 66 in the Missouri Ozarks. Arcadia Publishing. p. 62. ISBN 978-0-7385-6030-4.

v t e Municipalities and communities of Laclede County, Missouri, United States
County seat: Lebanon
Cities	Conway Lebanon Richland‡
Villages	Evergreen Phillipsburg Stoutland‡
Townships	Auglaize Eldridge Franklin Gasconade Lebanon May/Smith Osage Phillipsburg Spring Hollow Union Washington
CDP	Bennett Springs‡
Other unincorporated communities	Abo Agnes Bidwell Brownfield Brush Creek Caffeyville Carrol Junction Case Competition Delmar Dove Drew Drynob Eldridge Falcon Grace Hazelgreen Ira Lynchburg Lyons Morgan Nebo Oakland Origanna Orla Pease Prosperine Russ Sleeper Saint Annie Southard Winnipeg
Ghost towns	Atchley Corkery‡
Footnotes	‡This populated place also has portions in an adjacent county or counties
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37°36′07″N 92°42′45″W / 37.60194°N 92.71250°W / 37.60194; -92.71250

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