Campodonico is a surname of Italian origin, Donico being a town in Liguria, trading sea region of Northern Italy. Notable people with this surname include:
- Amanda Campodónico (1879–1933), Argentine mezzo-soprano singer
- César Campodónico (1929-2005), Uruguayan actor
- Elida Campodónico (1894-1960), Panamanian teacher, women's rights advocate and attorney
- Juan Campodónico (born 1971), Uruguayan musician, producer, composer, creator
- Mariano Campodónico (born 1974), Argentine football manager and former player
- Pablo Campodónico (born 1977), Argentine professional footballer
- Rodolfo Campodónico, one of the first composers of waltzes in Mexico
- Wally Campo (1923–2023), an American actor born as Wallace Joseph Campodonico.
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