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In enzymology, a channel-conductance-controlling ATPase (EC 3.6.3.49) is an enzyme that catalyzes the chemical reaction

ATP + H₂O ${\displaystyle \rightleftharpoons }$ ADP + phosphate

Thus, the two substrates of this enzyme are ATP and H₂O, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (channel-conductance-controlling).

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1XMI and 1XMJ.

References

• Chen M, Zhang JT (1996). "Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes". Mol. Membr. Biol. 13 (1): 33–40. doi:10.3109/09687689609160572. PMID 9147660.
• Tusnady GE, Bakos E, Varadi A, Sarkadi B (1997). "Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters". FEBS Lett. 402 (1): 1–3. Bibcode:1997FEBSL.402....1T. doi:10.1016/S0014-5793(96)01478-0. PMID 9013845. S2CID 30876895.
• Sheppard DN, Welsh MJ (1999). "Structure and function of the CFTR chloride channel". Physiol. Rev. 79 (1 Suppl): S23–45. doi:10.1152/physrev.1999.79.1.S23. PMID 9922375.

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