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Charles Sawyers

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American physician-scientist (born 1959)
Charles L. Sawyers
BornCharles Lazelle Sawyers
1959 (age 64–65)
Nashville, Tennessee
EducationJohns Hopkins University, Princeton, UCSF
Medical career
ProfessionPhysician
InstitutionsMemorial Sloan Kettering Cancer Center
Howard Hughes Medical Institute
Sub-specialtiesOncologist
ResearchLeukemia/prostate cancer
AwardsLasker Clinical Award (2009)
BBVA Foundation Frontiers of Knowledge Award (2014)
WebsiteThe Charles Sawyers Lab

Charles L. Sawyers (born 1959) is a Howard Hughes Medical Institute (HHMI) investigator who holds the Marie-Josée and Henry R. Kravis Chair of the Human Oncology and Pathogenesis Program (HOPP) at Memorial Sloan Kettering Cancer Center (MSK). HOPP is a program created in 2006 that comprises researchers from many disciplines to bridge clinical and laboratory discoveries.

Career

Sawyers received a BA from Princeton University in 1981 and an MD from Johns Hopkins University School of Medicine in 1985, followed by an internal medicine residency at the University of California, San Francisco. He became a HHMI investigator in 2002 while working at UCLA's Jonsson Cancer Center.

Sawyers works on molecularly targeted cancer drugs, with a focus on developing a new generation of treatment options for patients. He shared the 2009 Lasker-DeBakey Clinical Medical Research Award with Brian J. Druker and Nicholas Lydon, for the development of the ABL kinase inhibitor imatinib for patients with chronic myeloid leukemia and the second-generation ABL inhibitor dasatinib to overcome imatinib resistance. He also co-discovered the antiandrogen drugs enzalutamide, approved by the FDA in 2012, and apalutamide approved in 2019, both for treatment of advanced prostate cancer.

Sawyers' cancer research is discussed in the second episode of Cancer: The Emperor of All Maladies.

Significant positions

Sawyers served as president of the American Society for Clinical Investigation (ASCI) in 2007 and of the American Association for Cancer Research (AACR) in 2012. He was also appointed to the National Cancer Advisory Board by President Obama in 2012, and has served on the Board of Directors of Novartis since 2013. He was a founding co-editor of the Annual Review of Cancer Biology in 2017, serving until 2021.

Memberships

Awards

References

  1. Howard Hughes Medical Institute, Annual Scientific Report, The Institute, 1990, p. 507.
  2. "At Work: Human Oncology and Pathogenesis Program Chair Charles Sawyers | Memorial Sloan Kettering Cancer Center". www.mskcc.org. Retrieved 5 April 2017.
  3. "Susan Schneck Weds Charles Sawyers". The New York Times. 22 October 1990. Retrieved 3 March 2017.
  4. "UCSF Department of Medicine Alumni Profile: Dr. Charles Sawyers". medicine.ucsf.edu. Archived from the original on 8 September 2015. Retrieved 3 March 2017.
  5. "Charles L. Sawyers, MD". HHMI.org. Retrieved 5 April 2017.
  6. Grindlinger, Brooke; Chao, ES (1 October 2009). "Trio receives Lasker Foundation Clinical Award for breakthroughs in leukemia treatment". Journal of Clinical Investigation. 119 (10): 2863–2865. doi:10.1172/JCI41141. ISSN 0021-9738. PMC 2752112.
  7. Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL (2009). "Development of a second-generation antiandrogen for treatment of advanced prostate cancer". Science. 324 (5928): 787–90. Bibcode:2009Sci...324..787T. doi:10.1126/science.1168175. PMC 2981508. PMID 19359544.
  8. Reyes, Antonio A.; Akeson, Richard (1988). "Generation of Multiple Independent Substitution Mutants by M13 in Vitro Mutagenesis Using a Single Mutagenic Oligonucleotide". DNA. 7 (8): 579–584. doi:10.1089/dna.1.1988.7.579. PMID 3180999.
  9. "2008 American Society for Clinical Investigation Presidential Address" (PDF). the-asci.org. Retrieved 3 March 2017.
  10. "Charles L. Sawyers, MD". aacr.org. Retrieved 4 March 2017.
  11. "President Obama Announces More Key Administration Posts". whitehouse.gov. 6 December 2012. Retrieved 4 March 2017.
  12. "Charles L. Sawyers, M.D. Member of the Board of Directors" (PDF). novartis.com. Retrieved 4 March 2017.
  13. Jacks, Tyler; Sawyers, Charles (2017). "Introduction". Annual Review of Cancer Biology. 1: i. doi:10.1146/annurev-ca-01-121516-100001.
  14. "Annual Review of Cancer Biology Editorial Committee". Annual Reviews. 2022. Retrieved 18 July 2022.
  15. "Doris Duke Charitable Foundation Awards $10.5 Million for Medical Research". Philanthropy News Digest (PND). Retrieved 5 April 2017.
  16. "Recipients of the David A. Karnofsky Memorial Award and Lecture - The ASCO Post". www.ascopost.com. Archived from the original on 19 September 2017. Retrieved 5 April 2017.
  17. "Awards, Appointments, Announcements". JNCI Journal of the National Cancer Institute. 97 (11): 797. 1 June 2005. doi:10.1093/jnci/97.11.797.
  18. "Dorothy P. Landon-AACR Prize for Translational Cancer Research". www.aacr.org. Archived from the original on 3 September 2017. Retrieved 5 April 2017.
  19. Foundation, Lasker. "Molecularly targeted treatments for chronic myeloid leukemia | The Lasker Foundation". The Lasker Foundation. Retrieved 5 April 2017.
  20. "Breakthrough Prize". breakthroughprize.org. Retrieved 5 April 2017.
  21. "Taubman Prize". A. Alfred Taubman Medical Research Institute. Retrieved 16 March 2017.
  22. "2014 Honorees". The Hope Funds for Cancer Research. 5 September 2013. Retrieved 5 April 2017.
  23. "BBVA Foundation Frontiers of Knowledge Awards". www.fbbva.es. Archived from the original on 21 September 2015. Retrieved 5 April 2017.

External links

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