Chastain may refer to:
- Chastain (surname)
- Chastain, Georgia, a community in the United States
- Chastain Park, located in the Atlanta, Georgia area
- Chastain Peak, Thiel Mountains, Antarctica
- Chastain (band), an American heavy metal band
- Chastain Motorsports, team in Indy Racing League
- Chastain Park Memorial Hospital, fictional setting of Fox TV series The Resident (TV series)
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