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Chromonychia

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Chromonychia is an abnormality in color of the substance or surface of the nail plate or subungual tissues.

Chromonychia can be induced by antineoplastic drugs with few distinct forms, the most frequently seen is melanonychia. Although a few cytostatics may cause these changes, the drugs most commonly involved are adriamycin, cyclophosphamide and vincristine, or in polychemotherapy

Also chromonychia is associated with AIDS. A significant association (p<0.05) was found between chromonychia and CD4 counts of below 200 per cubic millimeter.

References

  1. Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
  2. Unamuno P, Fernández-López E, Santos C (July 1992). "Leukonychia due to cytostatic agents". Clin. Exp. Dermatol. 17 (4): 273–4. doi:10.1111/j.1365-2230.1992.tb02166.x. PMID 1451320.
  3. Chapman S, Cohen PR (April 1997). "Transverse leukonychia in patients receiving cancer chemotherapy". South. Med. J. 90 (4): 395–8. doi:10.1097/00007611-199704000-00006. PMID 9114829.
  4. Dasanu, Constantin A; Vaillant, JG; Alexandrescu, DT (October 31, 2006). "Distinct patterns of chromonychia, Beau's lines, and melanoderma seen with vincristine, adriamycin, dexamethasone therapy for multiple myeloma". Dermatology Online Journal. 12 (6): 10. PMID 17083890.
  5. Monsel G, Ly F, Canestri A, Diousse P, Ndiaye B, Caumes E (March 2008). "". Ann Dermatol Venereol (in French). 135 (3): 187–93. doi:10.1016/j.annder.2007.11.022. PMID 18374849.


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